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This scoping review aimed at mapping the literature on pain relief with anti\u2010OP drugs in OP treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Databases and Data Treatment<\/jats:title><jats:p>Medline, Pubmed and Cochrane databases were searched by two reviewers with keywords combinations. Randomized controlled and real\u2010life English studies, pain as an endpoint, antiosteoporosis drugs were inclusion criteria. Case reports, surveys, comment letters, conference abstracts, animal studies and grey literature were excluded. Predetermined data were extracted by two reviewers and disagreement solved through discussion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 130 articles were identified, 31 publications were included, 12 randomized clinical trials and 19 observational studies. Pain reduction was assessed by different tools: Visual Analogue Scale, Verbal Rating Scale, Facial Scale or as a domain of quality of life questionnaires including Short form 8, 36, mini\u2010OP, Japanese OP, Qualeffo, Roland Morris Disability questionnaires. Collective data show that anti\u2010OP drugs may display an analgesic effect that may be linked to the local mode of action of drugs on bone and consecutive modulation of pain sensitization. The methodology of the studies showed a heterogeneity of endpoints, comparators, statistical approaches and follow\u2010up duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Considering the limitations of the literature, there is a need for more rigorous trials and larger real\u2010life studies taking into account the recommendations published for research in rheumatology and in pain medicine. The identification of responders, patient subtypes, and of analgesic\u2010effect doses would allow optimization and individualization for pain relief in patients with OP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance Statement<\/jats:title><jats:p>This scoping review shows that anti\u2010OP drugs may improve pain and quality of life of patients with OP. The heterogeneity in design, choice of endpoints, methodology, comparators and follow\u2010up duration of included randomized clinical trials and real\u2010life studies does not allow so far to identify a predominant antiosteoporosis drug or an optimal dosage for pain relief. These gaps need to be addressed and warrant further research in the future for optimizing pain improvement in the course of OP drug treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2156","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T07:29:27Z","timestamp":1688542167000},"page":"3-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Osteoporosis treatment and pain relief: A scoping review"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6750-2038","authenticated-orcid":false,"given":"Marie\u2010Eva","family":"Pickering","sequence":"first","affiliation":[{"name":"Rheumatology Department CHU Gabriel Montpied  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose\u2010Marie","family":"Javier","sequence":"additional","affiliation":[{"name":"Centre d'Evaluation et de Traitement de la Douleur et Service de Rhumatologie H\u00f4pitaux Universitaires de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Malochet","sequence":"additional","affiliation":[{"name":"Rheumatology Department CHU Gabriel Montpied  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"Pickering","sequence":"additional","affiliation":[{"name":"Clinical Investigation Center, PIC\/CIC University Hospital, CHU  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Desmeules","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie et Toxicologie Cliniques, Centre multidisciplinaire de la douleur H\u00f4pitaux Universitaires de Gen\u00e8ve  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010152"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5069918"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001326"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.08.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00612-4"},{"key":"e_1_2_8_7_1","first-page":"2","article-title":"Raloxifene\u2010induced osteonecrosis of the jaw (MRONJ) with no exposure to bisphosphonates: Clinical and radiographic findings","author":"Bindakhil M.","year":"2021","journal-title":"Quintessence International (Berlin, Germany: 1985)"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(96)07088\u20102"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2018.02.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4158\/GL-2020-0524SUPPL"},{"key":"e_1_2_8_11_1","volume-title":"StatPearls [Internet]","author":"Casiano V. 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