{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T13:38:41Z","timestamp":1777815521788,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of long\u2010term opioid use after orthopaedic surgery varies from 1.4% to 24% and has mostly been studied with prescription data, making it difficult to estimate the size and impact of the problem. This study aims to assess the prevalence and predictors of long\u2010term postoperative opioid use in a high volume and tertiary orthopaedic centre by using online patient reported measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This Dutch prospective cohort study was conducted among adult patients who underwent any type of orthopaedic surgery from June to August 2021. Six months after surgery patients were invited to complete an online survey on current opioid use and patients' willingness to taper opioids. The demographics, clinical factors and preoperative opioid use were extracted from the patient file.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 607 patients (mean age 61.2\u2009years, 63.4% female) completed the survey. Seventy\u2010six patients (12.5%) used opioids 6\u2009months after surgery of which 20 (3.3%) did not use opioids before surgery. The median (Q1\u2013Q3) postoperative daily dose after 6\u2009months was 29.9\u2009mg (10.0\u201376.1) morphine equivalents. Most of them (88.2%) wanted to taper opioids. Affected body region (OR's: 6.84\u201312.75) and pre\u2010operative opioid use (OR\u2009=\u200935.33) were significant predictors of long\u2010term opioid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of long\u2010term postoperative opioid use was 12.5%; one in thirty patients became a new long\u2010term opioid user. Pre\u2010operative opioid use and affected body region were predictive for long\u2010term opioid use. These findings, together with the observation that long\u2010term opioid users want to taper opioids, emphasize the relevance of prevention, recognition and tapering support in the perioperative setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>Level II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Short\u2010term opioid use can unintentionally progress to long\u2010term opioid use. The prevalence of long\u2010term opioid use after orthopaedic surgery varies widely and is mostly prescription\u2010based, making it difficult to estimate the magnitude of the problem. This study assessed long\u2010term postoperative opioid use in a full breadth orthopaedic population using patient reported measures, making conclusions much more robust. The prevalence of long\u2010term postoperative opioid use in this study was 12.5%.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2219","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T15:04:00Z","timestamp":1702911840000},"page":"797-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long\u2010term postoperative opioid use in orthopaedic patients"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-3544","authenticated-orcid":false,"given":"Eward J.","family":"Melis","sequence":"first","affiliation":[{"name":"Department of Pharmacy Sint Maartenskliniek  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna E.","family":"Vriezekolk","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation Sint Maartenskliniek  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian C. 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E.","family":"Fenten","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Sint Maartenskliniek  Nijmegen The Netherlands"},{"name":"Department of Anaesthesiology, Pain and Palliative Care Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010022\u201001441\u20104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2020.03.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4964"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1908"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181\u2010012\u20100260\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010021\u201002145\u20105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt\u20102020\u20100048"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2021.09.007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001202"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.1464"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2196\/jmir.6.3.e34"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)00582\u20107"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.08.014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000108"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000516"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0168"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000000352"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17969"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010022\u201002266\u20105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010021\u201002091\u20102"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S91924"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010017\u20101769\u20109"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010020\u201001013\u2010y"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004510"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1901"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2021.02.044"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.12.086"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.00241"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002261"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.01005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010020\u201002184\u20101"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2013.846517"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain\u20102019\u20100170"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4091"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.12.046"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040\u20103590.7.4.524"},{"key":"e_1_2_10_38_1","first-page":"438","article-title":"The pain disability index: Psychometric and validity data","volume":"68","author":"Tait R. 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