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This cross\u2010sectional study aimed at identifying subgroups of people with chronic pain based on their psychological profiles, prescription opioid misuse, craving, and withdrawal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample comprised 185 individuals with chronic pain. We performed hierarchical cluster analysis on impulsivity, anxiety sensitivity, pain acceptance, pain intensity, opioid misuse, craving, and withdrawal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The four\u2010cluster solution was the optimal one. Misuse, craving, and anxiety sensitivity were higher among people in the Severe\u2010problems cluster than among people in the other three clusters. Withdrawal was the highest in the High\u2010withdrawal cluster. Impulsivity was higher among people in the Severe\u2010problems and High\u2010withdrawal clusters than those in the Moderate\u2010problems and Mild\u2010problems clusters. Pain acceptance was higher among people in the Mild\u2010problems cluster than among people in the other three clusters. Anxiety sensitivity and misuse were higher among people in the Moderate\u2010problems cluster than among people in the Mild\u2010problems cluster.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results support that impulsivity, anxiety sensitivity, and pain acceptance are useful constructs to identify subgroups of people with chronic pain according to their level of prescription opioid misuse, craving, and withdrawal. The results of this study may help in selecting the early intervention most suitable for each of the identified profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The psychological profile of individuals with chronic pain, prescription opioid misuse, craving, and withdrawal is characterized by fearing anxiety\u2010related symptoms due to the catastrophic interpretation of such symptoms and reacting impulsively to negative moods. In contrast, participants with high pain acceptance had less prescription opioid misuse, craving, and withdrawal. The profiles identified in this study could help clinicians select targets for intervention among profiles with similar needs and facilitate early interventions to prevent opioid misuse onset or aggravation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2233","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T09:45:25Z","timestamp":1704707125000},"page":"943-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Psychological profiles and prescription opioid misuse, craving, and withdrawal in people with chronic pain"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4474-7432","authenticated-orcid":false,"given":"R.","family":"Esteve","sequence":"first","affiliation":[{"name":"Facultad de Psicolog\u00eda y Logopedia Universidad de M\u00e1laga, Andaluc\u00eda Tech  M\u00e1laga Spain"},{"name":"Instituto de Investigaciones Biom\u00e9dicas de M\u00e1laga (IBIMA)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-4429","authenticated-orcid":false,"given":"V.","family":"Barrado\u2010Moreno","sequence":"additional","affiliation":[{"name":"Facultad de Psicolog\u00eda y Logopedia Universidad de M\u00e1laga, Andaluc\u00eda Tech  M\u00e1laga Spain"},{"name":"Instituto de Investigaciones Biom\u00e9dicas de M\u00e1laga (IBIMA)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3245-7844","authenticated-orcid":false,"given":"C.","family":"Ram\u00edrez\u2010Maestre","sequence":"additional","affiliation":[{"name":"Facultad de Psicolog\u00eda y Logopedia Universidad de M\u00e1laga, Andaluc\u00eda Tech  M\u00e1laga Spain"},{"name":"Instituto de Investigaciones Biom\u00e9dicas de M\u00e1laga (IBIMA)  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-5482","authenticated-orcid":false,"given":"E. 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