{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:30:18Z","timestamp":1772451018441,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between serum lipids and migraine is controversial. However, randomized controlled trials have suggested that statins may be efficacious for the prevention of migraine. In this study, we aim to investigate the relationship between lipids metabolism and migraine risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010nucleotide polymorphisms (SNPs), relating to the serum lipid traits and the effect of lipid\u2010lowering drugs that target <jats:italic>APOB<\/jats:italic>, <jats:italic>CETP<\/jats:italic>, <jats:italic>HMGCR<\/jats:italic>, <jats:italic>NPC1L1<\/jats:italic>, and <jats:italic>PCSK9<\/jats:italic>, were extracted from genome\u2010wide association studies (GWAS) summary data. The GWAS summary data were obtained from the Global Lipids Genetic Consortium (GLGC), the UK Biobank, and the FinnGen study, respectively. Mendelian randomization (MR) analysis was performed to evaluate the association between serum lipid traits and lipid\u2010lowering drugs with migraine risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding serum lipids, it was found that SNPs related to high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C), non\u2010high\u2010density lipoprotein cholesterol (non\u2010HDL\u2010C), total cholesterol (TC), or triglycerides (TG) levels were not associated with migraine, migraine with aura (MA) or migraine without aura (MO). In addition, genotypes of <jats:italic>HMGCR<\/jats:italic> related to higher LDL\u2010C levels were associated with increased risk of migraine (OR\u2009=\u20091.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.035) and MA (OR\u2009=\u20092.03, <jats:italic>p<\/jats:italic>\u2009=\u20090.008); However, genotypes of <jats:italic>PCSK9<\/jats:italic> related to higher LDL\u2010C levels were associated with decreased risk of migraine (OR\u2009=\u20090.75, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and MA (OR\u2009=\u20090.69, <jats:italic>p<\/jats:italic>\u2009=\u20090.004); And genotypes of <jats:italic>APOB<\/jats:italic> related to higher LDL\u2010C levels were associated with decreased risk of MO (OR\u2009=\u20090.62, <jats:italic>p<\/jats:italic>\u2009=\u20090.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a relationship between lipid metabolism characteristics and migraine risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Based on the genome\u2010wide association summary data, single\u2010nucleotide polymorphisms (SNPs) related to high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C), non\u2010high\u2010density lipoprotein cholesterol (non\u2010HDL\u2010C), total cholesterol (TC), or triglycerides (TG) level were not associated with risk of migraine, migraine with aura (MA) or migraine without aura (MO). However, genotypes of <jats:italic>HMGCR<\/jats:italic> related to higher LDL\u2010C levels have shown an increased risk on migraine and MA. And genotypes of <jats:italic>APOB<\/jats:italic> or <jats:italic>PCSK9<\/jats:italic> related to higher LDL\u2010C levels have shown a decreased risk on MO, or migraine and MA, respectively. These results suggested that there may be a relationship between lipid metabolism characteristics and the risk for migraine development.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2235","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T14:29:23Z","timestamp":1704551363000},"page":"978-986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mendelian randomization study of lipid metabolism characteristics and migraine risk"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-2685","authenticated-orcid":false,"given":"Peiwei","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Neurology, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu People's Republic of China"},{"name":"West China\u2010PUMC C.C. Chen Institute of Health Sichuan University  Chengdu People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu People's Republic of China"},{"name":"West China\u2010PUMC C.C. Chen Institute of Health Sichuan University  Chengdu People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Neurology, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu People's Republic of China"},{"name":"West China\u2010PUMC C.C. 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