{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:17:16Z","timestamp":1788491836743,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute physical activity leads to exercise\u2010induced hypoalgesia (EIH). However, to what degree it can be induced by very short but highly intensive exercise is largely unknown. This study aims to investigate the effects of two different short all\u2010out isokinetic exercise sessions on EIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty young male participants underwent three different interventions (90, 15\u2009s all\u2010out isokinetic cycling, respectively, and control) after an individualized low\u2010intensity warm\u2010up in a randomized\u2010controlled\u2010crossover design. Before (pre), after warm\u2010up (post 1) as well as immediately post\u2010intervention (post 2) pain sensitivity was measured employing pressure pain thresholds (PPT; in N) at the elbow, knee and ankle joints as well as the sternum and forehead. Performance parameters (e.g. lactate, perceived exertion, heart rate) were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A \u2018time\u2019\u2009\u00d7\u2009\u2018intervention\u2019\u2009\u00d7\u2009\u2018body site\u2019 interaction effect (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup> partial\u2009=\u20090.110) was observed for PPT. Both isokinetic interventions resulted in EIH at all body sites, even after ruling out any warm\u2010up effects, while effects were larger for 90 s (maximum increase of 25.7\u2009\u00b1\u200911.7\u2009N) compared to 15\u2009s (maximum increase of 19.3\u2009\u00b1\u200918.9\u2009N), and control (maximum increase of 8.0\u2009\u00b1\u20096.1\u2009N). Compared to control, 15\u2009s also resulted in hypoalgesic effects and differences were not observed at all sites. In this study, 90 s resulted in higher lactate, subjective exhaustion and heart rate levels compared to 15\u2009s and control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while higher values were also observed for 15\u2009s compared to control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Global EIH assessed immediately after exercise can be induced by short highly intensive exercises. The effects are greater when the subjective and the objective exertion are higher as induced by the 90\u2009s intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance Statement<\/jats:title><jats:p>This study investigates the potential for brief, highly intensive exercise sessions to induce exercise\u2010induced hypoalgesia (EIH). The research demonstrates that EIH can indeed be triggered by such short workouts, with greater effects observed during a 90 s session compared to a 15 s one, most likely due to higher subjective and objective exertion. These findings offer insights into the potential for extremely brief but intense exercises to alleviate pain, impacting exercise recommendations and pain management strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2276","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T03:55:16Z","timestamp":1713412516000},"page":"1536-1546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short all\u2010out isokinetic cycling exercises of 90 and 15 s unlock exercise\u2010induced hypoalgesia"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-4891","authenticated-orcid":false,"given":"Fabian","family":"Tomschi","sequence":"first","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4117-9257","authenticated-orcid":false,"given":"Holger","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-2526","authenticated-orcid":false,"given":"Thomas","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800412448120"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182662098"},{"key":"e_1_2_11_4_1","volume-title":"Borg's perceived exertion and pain scales","author":"Borg G.","year":"1998"},{"key":"e_1_2_11_5_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31827ab6e4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2004.011718"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12168"},{"key":"e_1_2_11_9_1","first-page":"917","article-title":"Isometric back exercise has different effect on pressure pain thresholds in healthy men and women","volume":"18","author":"Gajsar H.","year":"2017","journal-title":"Pain Medicine"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000340"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11332-019-00592-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz131"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.04.030"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/0953710021000057541-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2003.09.010"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90061-7"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01004.2016"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/app122211391"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ptsp.2018.04.022"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200029020-00002"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200102000-00018"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3307-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.26.1107"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198712000-00005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/21641846.2014.957484"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-1721-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.103.3.659-666"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.09.006"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12312"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S384306"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/smi.892"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.03.005"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2165\/11319670-000000000-00000"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-123645"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199213010-00003"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1034604"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2023.100133"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2023-0346"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12020222"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-022-04997-1"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.09.023"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000823"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2020.04.003"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.2276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:14:05Z","timestamp":1731586445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.2276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,17]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/ejp.2276"],"URL":"https:\/\/doi.org\/10.1002\/ejp.2276","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,17]]},"assertion":[{"value":"2023-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}