{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:29Z","timestamp":1786977689989,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The present study sought to determine the prevalence of chronic non\u2010cancer pain (CNCP) among older adult inpatients with polypharmacy. It also aimed to analyse prescription patterns and assess the therapy adequacy and patient complexity for those with and without CNCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 4\u2010year longitudinal study examined data from an exhaustive acute care hospital register on home\u2010dwelling older adult patients (\u226565) with polypharmacy. Commonly known combinations of potentially inappropriate medications were used to estimate therapy adequacy. Patient complexity was evaluated by comparing number of comorbidities and investigating physical and cognitive deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We determined a prevalence of CNCP of 9.7% among all older adult inpatients with polypharmacy, rising to 11.3% for those aged \u226585. Overall, CNCP patients were prescribed more drugs and had more comorbidities and physical and cognitive deficits than patients without CNCP. Older adult patients with CNCP received more analgesics, greater quantities of opioids, paracetamol and co\u2010analgesics and elevated opioid dosages. Older adult patients with CNCP aged \u226585 received fewer analgesics, opioids, non\u2010steroidal anti\u2010inflammatory drugs and co\u2010analgesics but more paracetamol. Older adult patients with CNCP were prescribed more potentially inappropriate medications involving opioids. In particular, 24.5% received an opioid and a hypnotic (benzodiazepine or Z\u2010drug), and 8.6% received an opioid and a gabapentinoid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Observed differences in medication use between older adult inpatients with or without CNCP may be relevant for clinical practice. Potentially inadequate co\u2010prescribing (such as hypnotics and opioids) affects a higher proportion of patients with CNCP and may have serious unintended consequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study describes differences in prescription patterns between people with and without chronic non\u2010cancer pain in a large dataset of 20,422 discharges. The differences found may be relevant to clinical practice. In particular, high co\u2010prescribing of opioids and hypnotics may have serious unintended consequences. Greater physical and cognitive deficits may indicate greater patient complexity, and appropriate interventions need to be developed to improve the management of this vulnerable patient group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.2298","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:02:24Z","timestamp":1717574544000},"page":"1645-1655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prescribing pattern insights from a longitudinal study of older adult inpatients with polypharmacy and chronic non\u2010cancer pain"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-5124","authenticated-orcid":false,"given":"Aljoscha N.","family":"Goetschi","sequence":"first","affiliation":[{"name":"General Internal Medicine University Hospital of Bern, University of Bern  Bern Switzerland"},{"name":"Graduate School for Health Sciences University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-3255","authenticated-orcid":false,"given":"Henk","family":"Verloo","sequence":"additional","affiliation":[{"name":"School of Health Sciences, HES\u2010SO Valais\u2013Wallis University of Applied Sciences and Arts Western Switzerland  Sion Switzerland"},{"name":"Service of Old Age Psychiatry Lausanne University Hospital and University of Lausanne  Prilly Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Wernli","sequence":"additional","affiliation":[{"name":"Swiss Centre of Expertise in the Social Sciences (FORS), Faculty of Social and Political Sciences University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-0198","authenticated-orcid":false,"given":"Maria M.","family":"Wertli","sequence":"additional","affiliation":[{"name":"General Internal Medicine University Hospital of Bern, University of Bern  Bern Switzerland"},{"name":"Department of General Internal Medicine Cantonal Hospital of Baden  Baden Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3523-5729","authenticated-orcid":false,"given":"Carla","family":"Meyer\u2010Massetti","sequence":"additional","affiliation":[{"name":"General Internal Medicine University Hospital of Bern, University of Bern  Bern Switzerland"},{"name":"Institute of Primary Health Care (BIHAM), University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-019-00742-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.18372"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200932060-00003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/15360288.2011.650364"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2019.12.09"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.09.011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238285"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.10.007"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","unstructured":"Chou R. Hartung D. Turner J. Blazina I. Chan B. Levander X. McDonagh M. Selph S. Fu R. &Pappas M.(2020).Opioid treatments for chronic pain.","DOI":"10.23970\/AHRQEPCCER229"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.05.031"},{"key":"e_1_2_11_13_1","volume-title":"Query \u2018git\u2019 credentials from \u2018R\u2019","author":"Cs\u00e1rdi G.","year":"2022"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2012.8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"e_1_2_11_16_1","volume-title":"Polypharmacy and medicines optimisation. Making it safe and sound","author":"Duerden M.","year":"2013"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.08.033"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13153"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.03.009"},{"key":"e_1_2_11_20_1","first-page":"1","volume-title":"Gesundheit in der Schweiz\u2013Fokus chronische Erkrankungen","author":"Gesundheitsobservatorium S.","year":"2015"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59259-668-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1136"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002396"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v040.i03"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.9.1107"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2022-4"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(05)70078-1"},{"key":"e_1_2_11_28_1","first-page":"543","article-title":"Potentially inappropriate medications in the elderly: The PRISCUS list","volume":"107","author":"Holt S.","year":"2010","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-014-1777-8"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730100-00009"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.2217\/pmt.12.83"},{"key":"e_1_2_11_32_1","unstructured":"Kanton Wallis. (2018).Jahresbericht 2018\u2014Schl\u00fcsselzahlen.https:\/\/www.vs.ch\/de\/web\/rapport\u2010annuel\/chiffres\u2010cles"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31822ebe11"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0621-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2446-0"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10926-023-10115-5"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200205150-00003"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.4414\/saez.2007.12854"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-017-0514-2"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12266"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S174741"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200205000-00016"},{"key":"e_1_2_11_43_1","volume-title":"R: A language and environment for statistical computing","author":"R development Core Team","year":"2022"},{"key":"e_1_2_11_44_1","volume-title":"Read data stored by \u2018Minitab\u2019, \u2018S\u2019, \u2018SAS\u2019, \u2018SPSS\u2019, \u2018Stata\u2019, \u2018Systat\u2019, \u2018Weka\u2019, \u2018dBase\u2019, \u2026 0.1.2","author":"R development Core Team","year":"2022"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206914"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005454.pub2"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.12.005"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2019.04.012"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2021-053"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13324"},{"key":"e_1_2_11_51_1","first-page":"6","volume-title":"Gesch\u00e4ftsbericht","author":"Spital Wallis","year":"2018"},{"key":"e_1_2_11_52_1","first-page":"16","article-title":"Appropriate use of NSAIDs: Considering cardiovascular risk in the elderly","volume":"62","author":"Stillman M. J.","year":"2007","journal-title":"Geriatrics"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.2196\/24205"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.03.008"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2086-6"},{"key":"e_1_2_11_57_1","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology and Norwegian Institute of Public Health. (2023).ATC\/DDD Index.https:\/\/www.whocc.no\/atc_ddd_index\/"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_11_59_1","volume-title":"Read excel files","author":"Wickham H.","year":"2023"},{"key":"e_1_2_11_60_1","volume-title":"Automate package and project setup","author":"Wickham H.","year":"2022"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60805-9"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f7033"},{"key":"e_1_2_11_63_1","volume-title":"Cancer pain relief: With a guide to opioid availability","author":"World Health Organization","year":"1996"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.2298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T05:16:46Z","timestamp":1729574206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.2298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,5]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ejp.2298"],"URL":"https:\/\/doi.org\/10.1002\/ejp.2298","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,5]]},"assertion":[{"value":"2024-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}