{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:58:05Z","timestamp":1747148285492,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T00:00:00Z","timestamp":1719100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Migraine is a genetically determined disorder that predisposes to recurrent episodes of headache. Interleukin (IL)\u201018 is a pro\u2010inflammatory cytokine that seems to play a role in migraine pathophysiology, and its genetic variants could potentially impact susceptibility to migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between <jats:italic>IL18<\/jats:italic> rs360717 and rs187238 genetic variants with migraine diagnosis and its clinical characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study was conducted with 152 people with migraine and 155 healthy controls, matched by sex, age, ethnicity, and body mass index. Clinical characteristics of migraine, as well as validated questionnaires regarding disability and impact of migraine, presence of allodynia, anxiety, depression, and hyperacusis were collected. Genotyping for <jats:italic>IL18<\/jats:italic> rs360717 and rs187238 variants was performed using real\u2010time polymerase chain reaction (qPCR) and TaqMan\u2122 method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>IL18<\/jats:italic> rs360717A and rs187238G alleles were associated with increased chance of being diagnosed with migraine (OR\u2009=\u20091.53, 95%CI 1.05\u20132.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.028 and OR\u2009=\u20091.46, 95%CI 1.00\u20132.14, <jats:italic>p<\/jats:italic>\u2009=\u20090.049, respectively). In the dominant model, the rs360717GA\u2009+\u2009AA genotypes were also associated with a higher chance of migraine than the GG genotype (OR\u2009=\u20091.69, 95%CI 1.05\u20132.73, <jats:italic>p<\/jats:italic>\u2009=\u20090.030). In women, in addition to the previous associations, there was also an effect of the variants on the chance of migraine in the codominant models and dominant models. Furthermore, among women, there was an influence on the prevalence of postdrome perception with rs360717GA\u2009+\u2009AA (OR\u2009=\u20093.04, 95%CI 1.10\u20138.42, <jats:italic>p<\/jats:italic>\u2009=\u20090.032) and rs187238CG\u2009+\u2009GG (OR\u2009=\u20092.97, 95%CI 1.08\u20138.21, <jats:italic>p<\/jats:italic>\u2009=\u20090.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>IL18<\/jats:italic> rs360717 and rs187238 variants were associated with migraine diagnosis and postdrome symptoms, especially in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study has demonstrated that <jats:italic>IL18<\/jats:italic> rs360717 and rs187238 variants play a role in migraine, influencing the chance of being diagnosed with migraine, particularly among women. There are prospects that <jats:italic>IL18<\/jats:italic> variants could be considered potential genetic biomarkers for migraine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.2302","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T03:44:41Z","timestamp":1719200681000},"page":"1685-1700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp><i>IL18<\/i><\/scp> rs360717 <scp>and<\/scp> rs187238 genetic variants are associated with migraine diagnosis"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-9227","authenticated-orcid":false,"given":"Aline","family":"Vitali\u2010Silva","sequence":"first","affiliation":[{"name":"Escola de Medicina Pontif\u00edcia Universidade Cat\u00f3lica Do Paran\u00e1  Londrina Brazil"},{"name":"Universidade Estadual de Londrina  Londrina 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