{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:00:25Z","timestamp":1793829625986,"version":"4.6.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Painful neuropathy is a pathological condition caused by numerous factors including diabetes, chemotherapy or cancer. ART26.12 is a novel fatty acid\u2010binding protein 5 inhibitor, which our group showed could prevent and treat persistent pain in a preclinical model of oxaliplatin\u2010induced peripheral neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the current study, the efficacy of orally dosed ART26.12 was tested in multiple neuropathy models of different aetiology. Paw withdrawal threshold to von Frey monofilaments and latency to escape a cold plate were used as measurements of mechanical and cold sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ART26.12 (25 and 50\u2009mg\/kg BID), dosed prior to the induction of paclitaxel\u2010induced peripheral neuropathy (PIPN), reversed mechanical allodynia induced by paclitaxel in both male and female rats, and ART26.12 (50\u2009mg\/kg BID) prevented the induction of PIPN in female rats. ART26.12 (50\u2009mg\/kg BID) also had a protective effect on body weight in the PIPN model. ART26.12 (25 and 100\u2009mg\/kg BID) reversed mechanical allodynia when treating established streptozotocin\u2010induced diabetic neuropathy in male rats. In a model of breast cancer\u2010induced bone pain in female rats, ART26.12 (100\u2009mg\/kg BID) reversed mechanical allodynia within 1\u2009h of dosing. In the same model, ART26.12 (25\u2009mg\/kg BID) reversed mechanical allodynia from day 4 of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, these preclinical data suggest that ART26.12 is a safe and efficacious therapeutic drug for continued development towards the prevention and treatment of peripheral neuropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance Statement<\/jats:title><jats:p>This work now shows that ART26.12, a novel and selective inhibitor of FABP5, can prevent and treat multiple preclinical models of peripheral neuropathy. Given its excellent safety profile, further work is warranted to develop ART26.12 as a potential therapeutic tool for pain management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4718","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T01:14:04Z","timestamp":1724721244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["ART26.12, a novel fatty acid\u2010binding protein 5 inhibitor, shows efficacy in multiple preclinical neuropathy models"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5507-1381","authenticated-orcid":false,"given":"W. 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