{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:51:49Z","timestamp":1753869109735,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neuropathic pain is pain due to a disease or lesion of the somatosensory system, and can be either spontaneous, evoked or both. Hyperpathia is a type of evoked pain defined by IASP as \u2018a painful syndrome characterized by an abnormally painful reaction to a stimulus, especially a repetitive stimulus, as well as an increased threshold\u2019. The literature is sparse, and definitions are unclear and inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The aim of this study was to examine for the presence of mechanical hyperpathia in a heterogeneous group of patients with peripheral neuropathic pain and correlate signs of hyperpathia with other sensory signs. Patients were examined with graded pinprick stimuli to obtain a stimulus\u2013response curve and repetitive pinprick stimuli to assess increase in pain over time and aftersensations. Then, patients were grouped based on the likelihood of having mechanical hyperpathia with either a steep stimulus\u2013response curve or a steep curve on the repetitive pinprick test and results were correlated to mechanical detection and pain thresholds and other outcomes from a full quantitative sensory testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 124 patients with documented peripheral neuropathic pain. Patients with a steep stimulus\u2013response curve did not overlap with patients with a steep curve on the repetitive pinprick test and both groups more often had decreased rather than increased detection and pain thresholds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study questions the concept of hyperpathia and suggests that more studies are needed to identify which symptoms and signs group together and might form a syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance Statement<\/jats:title><jats:p>Hyperpathia is a syndrome of evoked pain. It is poorly defined and little is known about its clinical presentation. Since it is part of pain symptomatology it is important to have a clear definition and understand the pathophysiology behind. This study explored signs of hyperpathia in a heterogeneous group of patients with peripheral neuropathic pain. We used stimulus\u2013response function and repetitive pinprick stimulation to group patients based on the IASP definition. More studies are needed to understand how symptoms and signs coincide.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4739","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:44:44Z","timestamp":1729233884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Signs of hyperpathia in chronic peripheral neuropathic pain"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-6299","authenticated-orcid":false,"given":"Malin Erika","family":"Carmland","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Danish Pain Research Center Aarhus University  Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Dall","family":"Kreutzfeldt","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-1394","authenticated-orcid":false,"given":"Peter Kolind","family":"Brask\u2010Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Danish Pain Research Center Aarhus University  Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels Staehelin","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Danish Pain Research Center Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2518-9335","authenticated-orcid":false,"given":"Flemming Winther","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0357-8628","authenticated-orcid":false,"given":"S\u00f8ren Hein","family":"Sindrup","sequence":"additional","affiliation":[{"name":"Department of Neurology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-0240","authenticated-orcid":false,"given":"Nanna Brix","family":"Finnerup","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Danish Pain Research Center Aarhus University  Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010019\u20103695\u20107"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2165"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20103959(00)00369\u20109"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl016"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000492"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00045.2019"},{"key":"e_1_2_11_8_1","unstructured":"Foerster O. 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