{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:14:04Z","timestamp":1774491244599,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma neurofilament light chain (NFL) has been measured as a biomarker of neuronal damage in various neurological disorders. Elevated tau and \u03b2\u2010amyloid levels have been found in patients with fibromyalgia (FM). The aim of the present study was to compare plasma neurofilament levels in fibromyalgia patients with normal controls and to investigate the correlation with clinical features and cognitive tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Plasma NFL levels were assessed in 33 FM patients and compared with 22 age\u2010matched controls. All patients were also assessed with clinical scales examining fibromyalgia disability, sleep quality and duration, fatigue, anxiety, and depression, and a neuropsychological battery examining executive function, verbal short\u2010term memory, and working memory, as well as attentional executive function and selective attention, interference sensitivity, and inhibition of automatic responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NFL levels were higher in FM patients (controls 6.19\u00b1\u20091.92; FM 17.28\u00b1\u200915.94\u2009pg\/mL ANOVA <jats:italic>p<\/jats:italic> 0.002). Working memory was the most impaired cognitive function significantly correlated with high NFL scores (Pearson <jats:italic>p<\/jats:italic> 0.034). Short sleep times also correlated with higher NFL scores (Pearson <jats:italic>p<\/jats:italic> 0.02) and poorer working memory performance (Pearson <jats:italic>p<\/jats:italic> 0.02). No correlation was found with indices of disease severity and duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasma NFL levels are elevated in fibromyalgia patients, suggesting neuronal damage and correlating with a slight decrease in working memory and short sleep duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance Statement<\/jats:title><jats:p>Plasma neurofilament levels are elevated in patients with fibromyalgia, regardless of disease severity and duration. Neurofilament levels are higher in patients with mild working memory impairment and sleep disorders. Subgroups of patients with primary neuronal damage phenomena could be individualized for prospective evaluation with regard to the possible development of cognitive decline and sleep disturbances, which would justify a tailored therapeutic approach.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4752","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T10:08:33Z","timestamp":1730714913000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma neurofilament light chain in fibromyalgia: A case control study exploring correlation with clinical and cognitive features"],"prefix":"10.1002","volume":"29","author":[{"given":"Maddalena","family":"Ruggieri","sequence":"first","affiliation":[{"name":"Neurophysiopathology Unit, Policlinico General Hospital, DiBrain Department Bari Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Paparella","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit, Policlinico General Hospital, DiBrain Department Bari Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Clemente","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit, Policlinico General Hospital, DiBrain Department Bari Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Libro","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit, Policlinico General Hospital, DiBrain Department Bari Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta Domenica","family":"Gargano","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit, Policlinico General Hospital, DiBrain Department Bari Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6567-5373","authenticated-orcid":false,"given":"Marina","family":"de Tommaso","sequence":"additional","affiliation":[{"name":"Neurophysiopathology Unit, Policlinico General Hospital, DiBrain Department Bari Aldo Moro University  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16192"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2017.1422699"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-199303000-00006"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.698157"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2020.10.011"},{"key":"e_1_2_10_7_1","first-page":"111","article-title":"Una versione abbreviata del test di Stroop: dati normativi nella popolazione italiana","volume":"12","author":"Caffarra P.","year":"2002","journal-title":"Nuova Rivista di Neurologia"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565648809540416"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1921-3"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-023-06836-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9485-2"},{"key":"e_1_2_10_12_1","first-page":"35","article-title":"The neuroprotective aspects of sleep","volume":"3","author":"Eugene A. 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