{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:51:56Z","timestamp":1792101116382,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of postoperative pain is notably high among the elderly population, which poses significant challenges for their postoperative recovery. In this study, we aimed to identify preoperative predictors for acute and chronic postoperative pain in patients undergoing lumbar spinal surgery through a longitudinal investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 75 patients (mean age 68.29\u2009\u00b1\u20095.60\u2009years) and collected their resting\u2010state electroencephalography (EEG) data two hours before the surgery. The aperiodic and periodic signal components were extracted from the resting\u2010state EEG using the Fitting Oscillations and One\u2010Over\u2010F algorithm. We also collected the preoperative pain ratings, demographic information and the Hospital Anxiety and Depression Scale from all patients. The postoperative pain ratings were collected ten times from Day 1 to Week 12 after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed a high incidence of postoperative acute and chronic pain among older patients. Preoperative pain and peak alpha frequency in resting\u2010state EEG were the primary predictors of acute postoperative pain. Although age is a significant predictor of chronic postoperative pain, its predictive performance is poor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, our study provides valuable insights into the complex pattern of preoperative EEG features, preoperative pain and age in predicting postoperative pain at different stages. Our findings highlight the significance of exploring preoperative features to identify patients who are at a higher risk of developing severe postoperative pain, which can aid in the development of more personalized and effective pain management strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The heightened occurrence of postoperative pain among the elderly presents formidable obstacles to their recuperation. This study delves into identifying preoperative factors influencing acute and chronic postoperative pain. Our findings indicate that preoperative pain and peak alpha frequency are crucial predictors of acute postoperative pain. However, the predictive performance for chronic postoperative pain is limited, although age was a significant predictor of chronic postoperative pain. These insights contribute to the identification of patients at elevated risk for severe acute and chronic postoperative pain, offering valuable guidance for pre\u2010surgical risk assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4757","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T08:38:26Z","timestamp":1732351106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preoperative resting\u2010state electrophysiological signals predict acute but not chronic postoperative pain"],"prefix":"10.1002","volume":"29","author":[{"given":"Qi","family":"Han","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Department of Pain Medicine Peking University People's Hospital  Beijing China"},{"name":"Key Laboratory for Neuroscience, Ministry of Education\/National Health Commission Peking University  Beijing China"},{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Anesthesiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Special Education and Rehabilitation Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Lu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Department of Pain Medicine Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Guo","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyue","family":"Zhao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Department of Pain Medicine Peking University People's Hospital  Beijing China"},{"name":"Key Laboratory for Neuroscience, Ministry of Education\/National Health Commission Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mental Health, Institute of Psychology Chinese Academy of Sciences  Beijing China"},{"name":"Department of Psychology University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02218-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.03.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2552\/abe399"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.97.118102"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_9_7_1","article-title":"An update on postoperative opioid use and alternative pain control following spine surgery","volume":"13","author":"Berardino K.","year":"2021","journal-title":"Orthopaedic Review"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.002"},{"issue":"359","key":"e_1_2_9_9_1","first-page":"351","article-title":"The transition of acute postoperative pain to chronic pain: An integrative overview of research on mechanisms","volume":"18","author":"Chapman C. 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