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Unrevealing links between pain and other motor and non\u2010motor symptoms (NMS) of PD may accelerate delivery of much needed precision pain medicine approaches for PwP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An exploratory, cross\u2010sectional analysis of the prospective, observational, multicentre, international study \u2018<jats:italic>The Non\u2010motor International Longitudinal, Real\u2010Life Study in PD \u2010 NILS<\/jats:italic>\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 109 PwP (41.3% women, age 64.29\u2009\u00b1\u20099.80\u2009years, disease duration 5.50 (2.44\u201310.89) years, H&amp;Y stage 2 (1\u20134), levodopa equivalent daily dose 575.00 (315.00\u20131004.00) mg), strong correlations were noted between the total burden of PD\u2010related pain and the total NMS burden (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.641) and moderate with disturbances of sleep\/fatigue (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.483), cognitive issues (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.445), motor complications (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.421), anxiety (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.441) and depression (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20090.451). In a multivariate linear regression analysis, motor complications (<jats:italic>B<\/jats:italic>\u2009=\u20092.063, 95% CI for B 1.152\u20132.974, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), sleep disturbances\/fatigue (<jats:italic>B<\/jats:italic>\u2009=\u20090.392, 95% CI for <jats:italic>B<\/jats:italic> 0.064\u20130.720, <jats:italic>p<\/jats:italic>\u2009=\u20090.020) and anxiety (<jats:italic>B<\/jats:italic>\u2009=\u20090.912, 95% CI for <jats:italic>B<\/jats:italic> 0.165\u20131.659, <jats:italic>p<\/jats:italic>\u2009=\u20090.017) significantly impacted the overall burden of pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In PwP, PD\u2010related pain is significantly impacted by motor complications, anxiety and sleep disturbances. A personalized, tailored approach to management of pain in PwP need to accurately identify\u00a0and tackle\u00a0all its interrelated symptoms. Whether successful management of motor complications, anxiety and sleep disturbances may contribute to pain relief in PwP for specified cohorts needs to be a focus of future randomized controlled clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance statement<\/jats:title><jats:p>This explorative analysis identifies the frequent overlap of chronic pain, motor complications, sleep disturbances and anxiety in Parkinson's disease and could help advance the development of precise and effective pain management strategies tailored to the needs of People with Parkinson's.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4765","type":"journal-article","created":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T22:58:21Z","timestamp":1735513101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pain in Parkinson's disease is impacted by motor complications, anxiety and sleep disturbances"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-5058","authenticated-orcid":false,"given":"Katarina","family":"Rukavina","sequence":"first","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience at King's College London  London UK"},{"name":"Parkinson's Foundation Centre of Excellence King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet","family":"Staunton","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience at King's College London  London UK"},{"name":"Parkinson's Foundation Centre of Excellence King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Zinzalias","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience at King's College London  London UK"},{"name":"Parkinson's Foundation Centre of Excellence King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena Krbot","family":"Skoric","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Poplawska\u2010Domaszewicz","sequence":"additional","affiliation":[{"name":"Department of Neurology Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pisani","sequence":"additional","affiliation":[{"name":"Centro Interdipartimentale di Ricerca in Ipertensione Arteriosa e Patologie Associate Federico II University of Naples  Naples Italy"},{"name":"Federico II University Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Bannister","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience at King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Ray","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience at King's College London  London UK"},{"name":"Parkinson's Foundation Centre of Excellence King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2023.2202416"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26125"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_449_20"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29878"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20629"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010017\u20108426\u2010y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21596"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.6.629"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26270"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1123"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106815"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27626"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD\u2010181474"},{"key":"e_1_2_7_15_1","unstructured":"Epidemiology W. 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