{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T06:32:56Z","timestamp":1785220376082,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying the subset of patients at risk for developing persistent pain after surgery is clinically important as they could benefit from targeted prevention measures. In this prospective study, we investigated if the preoperative assessment of the individual susceptibility to developing experimentally induced secondary hyperalgesia is associated with post\u2010thoracotomy pain at 2\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one patients scheduled to undergo a posterolateral thoracotomy were recruited before surgery and followed prospectively for 2\u2009months. The day before surgery, we experimentally induced secondary hyperalgesia at one of the two forearms and measured the change of perception to mechanical pinprick stimuli and the area of hyperalgesia. On postoperative Day 4, Day 15 and at the 2\u2010month follow\u2010up, patients were asked about their pain intensity at rest and during coughing and the area of secondary hyperalgesia around the scar as well as the change in perception to mechanical pinprick stimuli was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 41 patients that were recruited only 20 could be analysed. Forty per cent reported pain at the 2\u2010month follow\u2010up. All of them reported cough\u2010evoked pain and 10 per cent also reported pain at rest. A binary logistic regression model with both the magnitude and extent of experimentally induced secondary hyperalgesia was statistically significant (chi\u2010squared\u2009=\u200912.439, <jats:italic>p<\/jats:italic>\u2009=\u20090.002, McFadden <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.462) and showed excellent discriminative power (AUC\u2009=\u20090.938) for the presence or absence of cough\u2010evoked pain at the 2\u2009month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that the individual susceptibility to developing experimentally induced secondary hyperalgesia preoperatively may identify patients who are potentially vulnerable to develop persistent post\u2010thoracotomy pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Our data suggests that preoperatively assessed experimentally induced secondary hyperalgesia displays excellent discriminative power for the presence or absence of cough\u2010evoked pain 2\u2009months after thoracotomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4768","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T14:05:01Z","timestamp":1733753101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preoperative susceptibility to developing secondary hyperalgesia is associated with post\u2010thoracotomy pain at 2\u2009months"],"prefix":"10.1002","volume":"29","author":[{"given":"Solenn","family":"Gousset","sequence":"first","affiliation":[{"name":"Institute of Neuroscience (IoNS) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilien","family":"Cappe","sequence":"additional","affiliation":[{"name":"Institute for Experimental and Clinical Research (IREC) UCLouvain  Brussels Belgium"},{"name":"Department of Anesthesiology, Cliniques Universitaires Saint Luc UCLouvain  Brussels Belgium"},{"name":"Department of Cardiovascular and Thoracic Surgery, Cliniques Universitaires Saint\u2010Luc UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Lenoir","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience (IoNS) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Steyaert","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience (IoNS) UCLouvain  Brussels Belgium"},{"name":"Institute for Experimental and Clinical Research (IREC) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lavand'homme","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience (IoNS) UCLouvain  Brussels Belgium"},{"name":"Institute for Experimental and Clinical Research (IREC) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Mouraux","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience (IoNS) UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Institute for Experimental and Clinical Research (IREC) UCLouvain  Brussels Belgium"},{"name":"Department of Cardiovascular and Thoracic Surgery, Cliniques Universitaires Saint\u2010Luc UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6668-3217","authenticated-orcid":false,"given":"Emanuel N.","family":"van den Broeke","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience (IoNS) UCLouvain  Brussels Belgium"},{"name":"Health Psychology, Faculty of Psychology and Educational Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.06.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.12.010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200510000\u201000004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(95)01441\u20101"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1613"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304\u20103959(01)00278\u20100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000157121.71808.04"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200212000\u201000035"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004850"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001999"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO\u201009\u201018\u20100356\u2010LE"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002508\u2010200409000\u201000005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200510000\u201000020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002301"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540\u2010021\u201002943\u20107"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.004"},{"issue":"2","key":"e_1_2_10_18_1","first-page":"55","article-title":"Abnormal sensations evoked over the chest and persistent peri\u2010incisional chest pain after cardiac surgery","volume":"61","author":"Momeni M.","year":"2010","journal-title":"Acta Anaesthesiologica Belgica"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003166"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6688"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1768"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/picr.PICR_87_17"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2009.10.006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001413"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.10.040"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12659"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.14.7687"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00274.2019"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272599"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00651.2013"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010016\u20100267\u20103"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200011000\u201000024"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102020\u2010101292"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010199909000\u201000030"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.1983.tb09716.x"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.4768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T03:51:58Z","timestamp":1748231518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.4768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ejp.4768"],"URL":"https:\/\/doi.org\/10.1002\/ejp.4768","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]},"assertion":[{"value":"2024-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4768"}}