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This study aimed to characterise (very) early CRPS patients and explore potential subgroups to enhance understanding of its mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 113 early CRPS patients were recruited, with 89 undergoing physical assessments. Data included demographic information, work\u2010related factors, CRPS history and clinical features, body perception disturbances, quantitative sensory testing (QST), and a visuospatial attention task.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>QST identified deficits in detecting thermal and mechanical stimuli, alongside increased sensitivity to thermal and blunt pressure painful stimuli. Participants reported body perception disturbances similar to those of persistent CRPS. Visuospatial biases were observed in two subgroups of patients. Latent class analysis (LCA) of 85 participants, based on five clinical parameters, identified four profiles: <jats:italic>Mild<\/jats:italic>, <jats:italic>Moderate<\/jats:italic>, <jats:italic>Body Representation Disturbance<\/jats:italic> (BRD), and <jats:italic>Pressure Allodynia<\/jats:italic> CRPS. The <jats:italic>Mild<\/jats:italic> and <jats:italic>Moderate<\/jats:italic> profiles were associated with higher\u2010intensity trauma, with the latter showing worse outcomes. <jats:italic>BRD<\/jats:italic> and <jats:italic>Pressure Allodynia<\/jats:italic> CRPS followed mild trauma but exhibited the poorest outcomes. BRD CRPS displayed significant body perception disturbances, while Pressure Allodynia CRPS presented the highest sensitivity to pressure and psychosocial risk of chronification. Neither condition duration nor skin temperature effectively distinguished subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings emphasise the heterogeneity within (very) early CRPS patients and support the absence of a minimum required duration prior to the CRPS diagnosis. Central\/systemic mechanisms may play critical roles in severe cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study identifies distinct (very) early CRPS profiles, suggesting different pathophysiological mechanisms and challenging traditional classifications. It paves the way for improved diagnosis and tailored treatments.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4785","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T06:48:17Z","timestamp":1737182897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early CRPS Is a Heterogeneous Condition: Results From a Latent Class Analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-4332","authenticated-orcid":false,"given":"Marc\u2010Henri","family":"Louis","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Department of Physical and Rehabilitation Medicine Saint\u2010Luc University Hospital  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ry","family":"Legrain","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Psychological Sciences Research Institute Universit\u00e9 Catholique de Louvain  Louvain\u2010la\u2010Neuve Belgium"},{"name":"Louvain Bionics Universit\u00e9 Catholique de Louvain  Louvain\u2010la\u2010Neuve Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Aron","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieve","family":"Filbrich","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Health Psychology, Faculty of Psychology and Educational Sciences Katholieke Universiteit Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Henrard","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy &amp; Pharmacoepidemiology Research Group Louvain Drug Research Institute, Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Institute of Health and Society (IRSS) Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Barbier","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Saint\u2010Luc University Hospital  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Libouton","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Saint\u2010Luc University Hospital  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Mouraux","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Erasmus University Hospital, Universit\u00e9 Libre de Bruxelles  Brussels Belgium"},{"name":"Laboratory of Applied Biology, Research Unit in Applied Neurophysiology (LABNeuro) Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lambert","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Berquin","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Universit\u00e9 Catholique de Louvain  Brussels Belgium"},{"name":"Department of Physical and Rehabilitation Medicine Saint\u2010Luc University Hospital  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70143-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.813"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000234"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2014.01.500"},{"key":"e_1_2_10_6_1","first-page":"1038","article-title":"Development of the QuickDASH: COmparison of Three Item\u2010Reduction Approaches","volume":"87","author":"Beaton D. 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