{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:58:36Z","timestamp":1783857516377,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","award":["DNRF121"],"award-info":[{"award-number":["DNRF121"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Identify values that could predict the presence of increased pressure\u2010pain sensitivity independent of the migraine cycle through a single assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a secondary analysis of a previous study in which 198 episodic and chronic migraine patients were assessed during all phases of the migraine cycle. Pressure pain threshold (PPT) was assessed over the temporalis, cervical spine, hand, and leg. Migraine patients were divided into two sub\u2010groups: patients with increased pressure\u2010pain sensitivity (IPS) and with No IPS (No\u2010IPS). A Chi\u2010squared Automatic Interaction Detection decision tree analysis was used to identify predictors to be included in the IPS or NoIPS group. To assess the internal validity of the model, a tenfold cross\u2010validation was applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>161 (81%) patients were included in the IPS group, while 37 (19%) in the NoIPS group. Migraine patients with: (1) Temporalis PPT \u2264\u2009130\u2009kPa; (2) Temporalis PPT &gt;\u2009130\u2009kPa and \u2264\u2009197.5\u2009kPa and hand PPT \u2264\u2009347.33\u2009kPa; (3) Temporalis PPT &gt;\u2009197.5\u2009kPa and hand PPT \u2264\u2009315\u2009kPa; were correctly included in the IPS group with a sensitivity of 96%, a specificity of 81%, a positive predictive value of 96%, and a negative predictive value of 81%. The accuracy of the model and the cross\u2010validation analysis were respectively 93% and 92%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high internal validity suggests that our model could precisely predict the presence of IPS independently by the phase in which the assessment occurred. Trigeminal and hand PPT cut\u2010off values could be used to identify patients with IPS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.4787","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:28:53Z","timestamp":1737458933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cut\u2010Off Values Able to Identify Migraine Patients With Increased Pressure\u2010Pain Sensitivity Independent of the Migraine Cycle Through a Single Assessment: A Secondary Analysis of a Multicentre, Cross\u2010Sectional, Observational Study"],"prefix":"10.1002","volume":"29","author":[{"given":"Matteo","family":"Castaldo","sequence":"first","affiliation":[{"name":"Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Medicine and Surgery, Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology Labs University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Arendt\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Gastroenterology &amp; Hepatology, Mech\u2010Sense, Clinical Institute Aalborg University Hospital  Aalborg Denmark"},{"name":"Steno Diabetes Center North Denmark, Clinical Institute Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ponzano","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Department of Health Sciences (DISSAL) University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bovis","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Department of Health Sciences (DISSAL) University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Torelli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Headache Centre University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Finocchi","sequence":"additional","affiliation":[{"name":"Ospedale San Paolo, ASL 2 Savonese  Savona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-6738","authenticated-orcid":false,"given":"Stefano","family":"Di Antonio","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health University of Genova  Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000219"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.919623"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883\u2010020\u201001839\u20105"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010023\u201007118\u20108"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221082506"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnad048"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14261"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14459"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221084217"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16070934"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221080572"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002614"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001353"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010023\u201001651\u20109"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420954518"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.4787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:49:32Z","timestamp":1758721772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.4787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/ejp.4787"],"URL":"https:\/\/doi.org\/10.1002\/ejp.4787","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"2024-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4787"}}