{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:33:07Z","timestamp":1790404387135,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> disinhibition within the spinal dorsal horn has been implicated in pain hypersensitivity on injury in different neuropathic models. However, <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> alteration has been explored in only one study on trigeminal neuropathic pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study investigated the implication of <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> in trigeminal dynamic mechanical allodynia (<jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content>) obtained after chronic constriction of the infraorbital nerve (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IoN<\/jats:styled-content>), and explored the cellular and molecular mechanisms by which <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> dysfunction induced <jats:styled-content style=\"fixed-case\">DMA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our data demonstrated a significant decrease in labelling in two <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> cell markers, glutamate acid decarboxylase (<jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>67), and parvalbumin, in the medullary dorsal horn (<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>) of allodynic rats in comparison to sham rats. Increasing <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> by intracisternal injections of vigabatrin (<jats:styled-content style=\"fixed-case\">VGB<\/jats:styled-content>), a blocker of the catabolic enzyme <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> transaminase, alleviated pain behaviour and restored normal <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> cell marker expression in allodynic <jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>. Interestingly, intracisternal <jats:styled-content style=\"fixed-case\">VGB<\/jats:styled-content> administration also significantly decreased <jats:styled-content style=\"fixed-case\">PKC<\/jats:styled-content>\u03b3 staining, i.e., of its phosphorylated active form and the number of <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2 positive cells within the <jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>. These two markers were highly expressed in allodynic <jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The circuitry composed of <jats:styled-content style=\"fixed-case\">PKC<\/jats:styled-content>\u03b3 and <jats:styled-content style=\"fixed-case\">pERK<\/jats:styled-content>1\/2 cells is silent under physiological conditions but is activated after <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IoN<\/jats:styled-content>, therefore, switching touch stimuli to pain sensation. The decrease of <jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content> transmission constituted a key factor in the activation of this neuronal circuitry, which opens the gate for non\u2010noxious stimuli to reach nociceptive projection neurons in lamina <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.525","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T02:25:02Z","timestamp":1401330302000},"page":"85-96","source":"Crossref","is-referenced-by-count":22,"title":["Mechanism of <scp>GABA<\/scp> involvement in post\u2010traumatic trigeminal neuropathic pain: Activation of neuronal circuitry composed of <scp>PKC\u03b3<\/scp> interneurons and <scp>pERK<\/scp>1\/2 expressing neurons"],"prefix":"10.1002","volume":"19","author":[{"given":"W.","family":"Dieb","sequence":"first","affiliation":[{"name":"Neuropsycho\u2010pharmacologie des syst\u00e8mes dopaminergiques sous corticaux Universit\u00e9 d'Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hafidi","sequence":"additional","affiliation":[{"name":"Neuropsycho\u2010pharmacologie des syst\u00e8mes dopaminergiques sous corticaux Universit\u00e9 d'Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.09.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X1999000600003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1898"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00236-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/07367228609144599"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01360-4"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1379-10.2011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-02-01363.1995"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(80)90062-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.230362997"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00262-O"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90167-L"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04223"},{"key":"e_1_2_9_15_1","first-page":"527","article-title":"Isobolographic analysis of interaction between vigabatrin and baclofen in the formalin test in mice","volume":"53","author":"Czuczwar M.","year":"2001","journal-title":"Pol J Pharmacol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5120-08.2009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.12.2082"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513498898"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.02.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(98)00062-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702794"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(06)54001-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00341-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01808"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568007043336716"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/16040"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.14060"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6175-08.2009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.08.052"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06493"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01302-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02682-9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20482"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90065-5"},{"key":"e_1_2_9_35_1","first-page":"RA1","article-title":"Targets for antiepileptic drugs in the synapse","volume":"13","author":"Landmark C.J.","year":"2007","journal-title":"Med Sci Monit"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.10.010"},{"key":"e_1_2_9_37_1","first-page":"409","article-title":"Dose\u2010response relationship analysis of vigabatrin doses and their antinociceptive effects in the hot\u2010plate test in mice","volume":"60","author":"Luszczki J.J.","year":"2008","journal-title":"Pharmacol Rep"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200205000-00020"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5336.279"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07302.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.02.007"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.05.013"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.4.2171"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1259-08.2008"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199605000-00024"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00241499"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01500-0"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.06.011"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1490-05.2005"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00011-3"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.07.009"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.3.1494"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2008"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.12.016"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7668"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00811-0"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.1.169"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00256-1"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2947"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00481-9"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10410"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00856.2002"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejp.525","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:09:21Z","timestamp":1695514161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,28]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/ejp.525"],"URL":"https:\/\/doi.org\/10.1002\/ejp.525","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,28]]}}}