{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:48:54Z","timestamp":1790790534978,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"OxfordMedical Knowledge","award":["None"],"award-info":[{"award-number":["None"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous analysis of a single data set in acute pain following third molar extraction demonstrated a strong relationship between the speed of reduction of pain intensity and overall pain relief, as well as need for additional analgesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individual patient data analysis of a single randomized, double\u2010blind trial of placebo, paracetamol 1000\u2009mg, ibuprofen sodium 400\u2009mg and ibuprofen\u2010poloxamer 400\u2009mg following third molar extraction. Visual analogue scale pain intensity (<jats:styled-content style=\"fixed-case\">VASPI<\/jats:styled-content>) and other measurements were made at baseline, every 5\u201345\u2009min, and at 60, 90, 120, 180, 240, 300 and 360\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients produced consistent <jats:styled-content style=\"fixed-case\">VASPI<\/jats:styled-content> results over time. For placebo and paracetamol, few patients achieved low <jats:styled-content style=\"fixed-case\">VASPI<\/jats:styled-content> scores and maintained them. For both ibuprofen formulations, <jats:styled-content style=\"fixed-case\">VASPI<\/jats:styled-content> scores fell rapidly during the first hour and were then typically maintained until later re\u2010medication. Analysis of all patients showed that rapid <jats:styled-content style=\"fixed-case\">VASPI<\/jats:styled-content> reduction in the first hour was strongly correlated with good overall pain relief (high total pain relief over 0\u20136\u2009h), and with lesser need for additional analgesia within 6\u2009h. Results for this analysis were in very good agreement with a previous analysis, validating the relationship between fast initial pain intensity reduction and overall good pain relief in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In acute pain following third molar extraction, faster acting analgesic formulations provide earlier onset of pain relief, better overall pain relief and a less frequent need for additional analgesia, indicating longer lasting pain relief.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.536","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T09:48:43Z","timestamp":1400752123000},"page":"187-192","source":"Crossref","is-referenced-by-count":34,"title":["Validating speed of onset as a key component of good analgesic response in acute pain"],"prefix":"10.1002","volume":"19","author":[{"given":"R.A.","family":"Moore","sequence":"first","affiliation":[{"name":"Pain Research and Nuffield Division of Anaesthetics Nuffield Department of Neurosciences University of Oxford  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Derry","sequence":"additional","affiliation":[{"name":"Pain Research and Nuffield Division of Anaesthetics Nuffield Department of Neurosciences University of Oxford  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Straube","sequence":"additional","affiliation":[{"name":"Institute of Occupational, Social and Environmental Medicine University Medical Center G\u00f6ttingen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ireson\u2010Paine","sequence":"additional","affiliation":[{"name":"Spreadsheet Factory  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Wiffen","sequence":"additional","affiliation":[{"name":"Pain Research and Nuffield Division of Anaesthetics Nuffield Department of Neurosciences University of Oxford  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6977.452"},{"key":"e_1_2_11_3_1","first-page":"117","volume-title":"The Design of Analgesic Clinical Trials (Advances in Pain Research and Therapy","author":"Cooper S.A.","year":"1991"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-009-0614-y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.09.019"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.129"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02723.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008659.pub2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.08.013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12148"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.09.021"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1998.tb05083.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.635"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejp.536","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejp.536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T16:26:18Z","timestamp":1696609578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/ejp.536"],"URL":"https:\/\/doi.org\/10.1002\/ejp.536","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}