{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:19:26Z","timestamp":1759133966508},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of this study was to explore the nociceptive system of patients affected by trigeminal neuralgia (TN<\/jats:styled-content>) secondary to documented vascular contact who underwent microvascular decompression. For that purpose, we used the classical trigeminal reflexes and the trigeminal laser\u2010evoked potentials (tLEPs<\/jats:styled-content>) before and after surgery, in order to verify any possible change after decompression and determine if there was any correlation between the neurophysiological parameters and the clinical outcome.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eleven patients affected by TN<\/jats:styled-content> caused by trigeminovascular contact and 10 age\u2010matched controls underwent conventional trigeminal reflexes (bilateral B<\/jats:styled-content>link R<\/jats:styled-content>eflex\/BR<\/jats:styled-content> and M<\/jats:styled-content>asseter I<\/jats:styled-content>nhibitory R<\/jats:styled-content>eflex stimulating infraorbital and mental nerves\/MIR V2<\/jats:styled-content> and V3<\/jats:styled-content>) and tLEPs. Patients repeated neurophysiological tests one week after surgery.<\/jats:p><\/jats:sec>Results<\/jats:title>Short\u2010latency BR<\/jats:styled-content> and MIR<\/jats:styled-content> were normal in all patients before surgery and there was no statistical difference before and after surgery. Conversely, in patients before surgery, tLEPs<\/jats:styled-content>' amplitudes were significantly lower in the affected than in the healthy side (p<\/jats:italic>\u2009=\u20090.017 for V2<\/jats:styled-content> and 0.037 for V3<\/jats:styled-content> branches). After surgery, on the affected side, tLEP<\/jats:styled-content> amplitude increased and the pre\/post\u2010operative difference was significant (p<\/jats:italic>\u2009=\u20090.017 for V2<\/jats:styled-content> and 0.028 for V3<\/jats:styled-content> divisions). Nine patients referred satisfactory pain relief and the favourable clinical outcome correlated with the neurophysiological recovery.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study demonstrates that TN<\/jats:styled-content> caused by trigeminovascular compression may be related to A<\/jats:styled-content>\u03b4 fibres impairment, and tLEPs<\/jats:styled-content> are more sensitive than conventional trigeminal reflexes to reveal small fibre dysfunction and to monitor the post\u2010surgical outcome in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.543","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T02:14:46Z","timestamp":1406600086000},"page":"253-259","source":"Crossref","is-referenced-by-count":5,"title":["Trigeminal laser\u2010evoked potentials: A neurophysiological tool to detect post\u2010surgical outcome in trigeminovascular contact neuralgia"],"prefix":"10.1002","volume":"19","author":[{"given":"G.","family":"Squintani","sequence":"first","affiliation":[{"name":"Neurology Unit Department of Neurocience Azienda Ospedaliera Universitaria Integrata Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Turri","sequence":"additional","affiliation":[{"name":"Department of Neurological, Neuropsychological, Morphological and Movement Sciences Section of Clinical Neurology University of Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Donato","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Neurocience Azienda Ospedaliera Universitaria Integrata Verona Italy"},{"name":"Department of Pharmacology University of Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tinazzi","sequence":"additional","affiliation":[{"name":"Department of Neurological, Neuropsychological, 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