{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:12:40Z","timestamp":1788869560766,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS077882"],"award-info":[{"award-number":["NS077882"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS078263"],"award-info":[{"award-number":["NS078263"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA020305"],"award-info":[{"award-number":["AA020305"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Headache is one of the most common symptoms following traumatic head injury. The mechanisms underlying the emergence of such post\u2010traumatic headache (\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      ) remain unknown but may be related to injury of deep cranial tissues or damage to central pain processing pathways, as a result of brain injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A mild closed head injury in mice combined with the administration of cranial or hindpaw formalin tests was used to examine post\u2010traumatic changes in the nociceptive processing from deep cranial tissues or the hindpaw. Histological analysis was used to examine post\u2010traumatic pro\u2010inflammatory changes in the calvarial periosteum, a deep cranial tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 48\u2009h after head injury, mice demonstrated enhanced nociceptive responses following injection of formalin into the calvarial periosteum, a deep cranial tissue, but no facilitation of the nociceptive responses following injection of formalin into an extracranial tissue, the hindpaw. Mice also showed an increase in the number of activated periosteal mast cells 48\u2009h following mild head trauma, suggesting an inflammatory response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our study demonstrates that mild closed head injury is associated with enhanced processing of nociceptive information emanating from trigeminal\u2010innervated deep cranial tissues, but not from non\u2010cranial tissues. Based on these finding as well as the demonstration of head injury\u2010evoked degranulation of calvarial periosteal mast cells, we propose that inflammatory\u2010evoked enhancement of peripheral cranial nociception, rather than changes in supraspinal pain mechanisms play a role in the initial emergence of\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      . Peripheral targeting of nociceptors that innervate the calvaria may be used to ameliorate\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      pain.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.583","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T02:15:02Z","timestamp":1409278502000},"page":"621-628","source":"Crossref","is-referenced-by-count":35,"title":["Mild closed head injury promotes a selective trigeminal hypernociception: Implications for the acute emergence of post\u2010traumatic headache"],"prefix":"10.1002","volume":"19","author":[{"given":"T.","family":"Benromano","sequence":"first","affiliation":[{"name":"Department of Anatomy and Anthropology Sackler Faculty of Medicine Tel Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Defrin","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Sackler Faculty of Medicine Tel Aviv University  Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida College of Medicine  Gainesville USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Critical Care and Pain Medicine Beth Israel Deaconess Medical Center Harvard Medical School  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.G.","family":"Pick","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology Sackler Faculty of Medicine Tel Aviv University  Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Critical Care and Pain Medicine Beth Israel Deaconess Medical Center Harvard Medical School  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Ahn A.H. Martin E. Basbaum A.I.(2008).A behavioral model of episodic cranial pain in mice conditions a place aversion. Program No. 267.15. Neuroscience Meeting Planner.Washington DC:Society for Neuroscience. 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