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Conflicting sensory stimuli can also generate unpleasant sensations in healthy people such as during motion sickness. We wanted to investigate the mechanisms underlying the link between sensory conflicts and pain in <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> using optokinetic stimulation (<jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content>) \u2013 a method known to induce motion sickness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> patients underwent <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content> and rated symptoms of motion sickness. Patients also rated limb pain and pain\u2010related distress before, during and after <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content>. In addition, pressure\u2010pain and sharpness sensations were investigated on both sides of the forehead and in the affected and contralateral limb before and after <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Limb pain and forehead hyperalgesia to pressure increased in parallel in response to <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content>. In a subgroup of nauseated patients who withdrew early from <jats:styled-content style=\"fixed-case\">OKS<\/jats:styled-content>, hyperalgesia to pressure in the ipsilateral forehead persisted longer than in the remaining participants. Sharpness sensations remained constant at all sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sensory conflicts may facilitate pain in <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> by activating the mechanisms of general facilitation of nociception and, during more severe sensory conflicts, also a facilitatory mechanism that operates mainly ipsilateral to the affected limb.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.602","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T07:25:51Z","timestamp":1413444351000},"page":"781-788","source":"Crossref","is-referenced-by-count":6,"title":["Optokinetic stimulation increases limb pain and forehead hyperalgesia in complex regional pain syndrome"],"prefix":"10.1002","volume":"19","author":[{"given":"L.F.","family":"Knudsen","sequence":"first","affiliation":[{"name":"School of Psychology and Exercise Science Murdoch University  Perth 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