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Whether this also occurs with <jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>\u20108825, a novel anti\u2010migraine drug also acting through <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content> receptor blockade (but chemically unrelated to olcegepant) was tested in the present study, which also investigated possible anti\u2010neuroinflammatory effects of this drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult male <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats underwent unilateral chronic constriction injury (<jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>) to either the <jats:styled-content style=\"fixed-case\">ION<\/jats:styled-content> or the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>, and mechanical allodynia was assessed 2 weeks later within the ipsilateral vibrissae territory or hindpaw, respectively. Transcripts of neuroinflammatory markers were quantified by real\u2010time quantitative <jats:styled-content style=\"fixed-case\">RT\u2010PCR<\/jats:styled-content> in ipsilateral trigeminal ganglion and spinal trigeminal nucleus in <jats:styled-content style=\"fixed-case\">CCI\u2010ION<\/jats:styled-content> rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acute as well as repeated (for 4 days) administration of <jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>\u20108825 (30\u2013100\u2009mg\/kg, i.p.) significantly reduced <jats:styled-content style=\"fixed-case\">CCI\u2010ION<\/jats:styled-content>\u2010induced mechanical allodynia but was ineffective in <jats:styled-content style=\"fixed-case\">CCI\u2010SN<\/jats:styled-content> rats. <jats:styled-content style=\"fixed-case\">CCI\u2010ION<\/jats:styled-content> was associated with marked up\u2010regulation of neuronal and glial inflammatory markers (<jats:styled-content style=\"fixed-case\">ATF<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>6, i<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>2) in ipsilateral trigeminal ganglion but not spinal trigeminal nucleus. <jats:styled-content style=\"fixed-case\">MK<\/jats:styled-content>\u20108825\u2010induced inhibition of i<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> up\u2010regulation probably underlay its anti\u2010allodynic effect because pharmacological blockade of i<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content> by <jats:styled-content style=\"fixed-case\">AMT<\/jats:styled-content> (6\u2009mg\/kg, s.c.) mimicked this effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data further support the idea that <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content> receptor blockade might be a valuable approach to alleviate trigeminal, but not spinal, neuropathic pain through, at least partly, an inhibitory effect on neuropathic pain\u2010associated increase in <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> production in trigeminal ganglion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.616","type":"journal-article","created":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T08:14:29Z","timestamp":1415175269000},"page":"281-290","source":"Crossref","is-referenced-by-count":29,"title":["<scp>CGRP<\/scp> receptor blockade by <scp>MK<\/scp>\u20108825 alleviates allodynia in infraorbital nerve\u2010ligated rats"],"prefix":"10.1002","volume":"19","author":[{"given":"B.","family":"Michot","sequence":"first","affiliation":[{"name":"INSERM U894 CPN  Paris France"},{"name":"Neuropsychopharmacology Faculty of Medicine Pierre &amp; 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