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At the same time, it is probably one of the most dangerous compounds in medical use, causing hundreds of deaths in all industrialized countries due to acute liver failure (\n                    <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>\n                    ). Publications of the last 130 years found in the usual databases were analyzed. Personal contacts existed to renowned researchers having contributed to the medical use of paracetamol and its precursors as\n                    <jats:styled-content style=\"fixed-case\">H.U. Z<\/jats:styled-content>\n                    ollinger,\n                    <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                    oeschlin,\n                    <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                    ubach,\n                    <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                    .\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    xelrod and others. Further information is found in earlier reviews by\n                    <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                    ichengr\u00fcn, Rodnan and\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    enedek,\n                    <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                    neader,\n                    <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                    rune; comp. references. The history of the discovery of paracetamol starts with an error (active against worms), continues with a false assumption (paracetamol is safer than phenacetin), describes the first side\u2010effect \u2018epidemy\u2019 (phenacetin nephropathy, drug\u2010induced interstitial nephritis) and ends with the discovery of second\u2010generation problems due to the unavoidable production of a highly toxic metabolite of paracetamol\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>N<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010acetyl\u2010\n                    <jats:italic>p<\/jats:italic>\n                    \u2010benzoquinone imine (\n                    <jats:styled-content style=\"fixed-case\">NAPQI<\/jats:styled-content>\n                    ) that may cause not only\n                    <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content>\n                    and kidney damage but also impaired development of the fetus and the newborn child. It appears timely to reassess the risk\/benefit ratio of this compound.\n                  <\/jats:p>","DOI":"10.1002\/ejp.621","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T04:41:59Z","timestamp":1417754519000},"page":"953-965","source":"Crossref","is-referenced-by-count":182,"title":["Acetaminophen\/paracetamol: A history of errors, failures and false decisions"],"prefix":"10.1002","volume":"19","author":[{"given":"K.","family":"Brune","sequence":"first","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology University of Erlangen\u2010N\u00fcrnberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Renner","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology University of Erlangen\u2010N\u00fcrnberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tiegs","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology and Hepatology University Medical Center Hamburg\u2010Eppendorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1313942"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.28.040188.000245"},{"key":"e_1_2_8_4_1","unstructured":"Bateman D.N. 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