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Therefore, the further search for principally new prophylactic antimigraine agents remains an important task. The objective of our study was to evaluate the effects of a fixed combination of dextromethorphan hydrobromide and quinidine sulphate (<jats:styled-content style=\"fixed-case\">DM\/Q<\/jats:styled-content>) on activity of the spinal trigeminal neurons in an electrophysiological model of trigemino\u2010durovascular nociception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was performed in 15 male <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>istar rats, which were anaesthetized with urethane\/\u03b1\u2010chloralose and paralysed using pipecuronium bromide. The effects of cumulative intravenous infusions of <jats:styled-content style=\"fixed-case\">DM\/Q<\/jats:styled-content> (three steps performed 30\u2009min apart, 15\/7.5\u2009mg\/kg of <jats:styled-content style=\"fixed-case\">DM\/Q<\/jats:styled-content> in 0.5\u2009mL of isotonic saline per step) on ongoing and dural electrical stimulation\u2010induced neuronal activities were tested in a group of eight rats over 90\u2009min. Other seven animals received cumulative infusion of equal volumes of saline and served as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative administration of <jats:styled-content style=\"fixed-case\">DM\/Q<\/jats:styled-content> produced steady suppression of both the ongoing activity of the spinal trigeminal neurons and their responses to electrical stimulation of the dura mater.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is evident that the observed <jats:styled-content style=\"fixed-case\">DM\/Q<\/jats:styled-content>\u2010induced suppression of trigeminal neuron excitability can lead to a reduction in nociceptive transmission from meninges to higher centres of the brain. Since the same mechanism is believed to underlie the pharmacodynamics of many well\u2010known antimigraine drugs, results of the present study enable us to anticipate the potential efficacy of <jats:styled-content style=\"fixed-case\">DM\/Q<\/jats:styled-content> in migraine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.631","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:48:03Z","timestamp":1416469683000},"page":"1086-1094","source":"Crossref","is-referenced-by-count":10,"title":["Intravenous dextromethorphan\/quinidine inhibits activity of dura\u2010sensitive spinal trigeminal neurons in rats"],"prefix":"10.1002","volume":"19","author":[{"given":"A.Y.","family":"Sokolov","sequence":"first","affiliation":[{"name":"Department of Neuropharmacology Valdman Institute of Pharmacology First St. Petersburg Pavlov State Medical University  Russia"},{"name":"Laboratory of Cortico\u2010Visceral Physiology Pavlov Institute of Physiology Russian Academy of 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