{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:37:31Z","timestamp":1761975451323,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"crossref","award":["(NSC 100-2314-B-010-006-MY3, NSC 100-2629-B-010-001, NSC 101-2629-B-010-001, NSC 102-2629-B-010-001"],"award-info":[{"award-number":["(NSC 100-2314-B-010-006-MY3, NSC 100-2629-B-010-001, NSC 101-2629-B-010-001, NSC 102-2629-B-010-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rimary dysmenorrhoea (<jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>) is inexorably common. <jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content> women suffer from cramping pain in the lower abdomen that starts with menstruation and lasts for 24\u201372\u2009h. Up to 90% of adolescent girls and more than 50% of menstruating women worldwide report suffering from it. Ten to 20% of <jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content> women describe their suffering as severe and distressing. However, nothing is known regarding the association of <jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content> with possible brain anomalies or abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010resolution <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1\u2010weighted anatomical brain magnetic resonance images (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) were acquired for each subject and inspected for incidental findings (normal variants and abnormalities) as a routine procedure in our <jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>\u2010related multimodal neuroimaging studies. Altogether, 330 right\u2010handed young women [otherwise healthy <jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>s\u2009=\u2009163; non\u2010<jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content> healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s)\u2009=\u2009167] were enrolled during the period of 2006\u20132014. Binomial proportion test was performed for between\u2010group comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>s demonstrated significantly higher prevalence of overall incidental brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings (<jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>s: <jats:italic>n<\/jats:italic>\u2009=\u200918, 11.0%; <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s: <jats:italic>n<\/jats:italic>\u2009=\u20096, 3.6%; <jats:italic>p<\/jats:italic>\u2009=\u20090.005) that should be ascribed to a preponderance of normal variants (<jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>s: <jats:italic>n<\/jats:italic>\u2009=\u200916, 9.8%; <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s: <jats:italic>n<\/jats:italic>\u2009=\u20093, 1.8%; <jats:italic>p<\/jats:italic>\u2009=\u20090.001), especially cavum septum pellucidum. No significant between\u2010group difference of abnormal findings was found (<jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>s: <jats:italic>n<\/jats:italic>\u2009=\u20092, 1.2%; <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>s: <jats:italic>n<\/jats:italic>\u2009=\u20093, 1.8%; <jats:italic>p<\/jats:italic>\u2009=\u20090.336).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We report here that otherwise healthy <jats:styled-content style=\"fixed-case\">PDM<\/jats:styled-content>s are associated with high prevalence of normal variants but not brain abnormalities. Our observations invite further epidemiological and neuroscientific studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.639","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T07:21:18Z","timestamp":1418109678000},"page":"1071-1074","source":"Crossref","is-referenced-by-count":18,"title":["High prevalence of incidental brain findings in primary dysmenorrhoea"],"prefix":"10.1002","volume":"19","author":[{"given":"W.C.","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.H.","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Integrated Brain Research Unit Division of Clinical Research Department of Medical Research Taipei Veterans General Hospital  Taiwan"},{"name":"Department of Education and Research Taipei City Hospital  Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.T.","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Taipei Veterans General Hospital  Taiwan"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine School of Medicine National Yang\u2010Ming University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.C.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Integrated Brain Research Unit Division of Clinical Research Department of Medical Research Taipei Veterans General Hospital  Taiwan"},{"name":"Department of Radiology Taipei Veterans General Hospital  Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.F.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Integrated Brain Research Unit Division of Clinical Research Department of Medical Research Taipei Veterans General Hospital  Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Institute of Brain Science School of Medicine National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Integrated Brain Research Unit Division of Clinical Research Department of Medical Research Taipei Veterans General Hospital  Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Primary dysmenorrhea: An urgent mandate","volume":"21","author":"Berkley K.J.","year":"2013","journal-title":"Pain: Clin Updates"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.04.013"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20180"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00442.x"},{"key":"e_1_2_7_6_1","first-page":"245","volume-title":"Imaging of the Brain","author":"Rios J.C.","year":"2012"},{"volume-title":"Langman's Medical Embryology","year":"2011","author":"Sadler T.W.","key":"e_1_2_7_7_1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.09.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.05.026"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.080"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.022"},{"volume-title":"Primer of Diagnostic Imaging","year":"2011","author":"Weissleder R.","key":"e_1_2_7_12_1"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejp.639","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:00:07Z","timestamp":1696338007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,8]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/ejp.639"],"URL":"https:\/\/doi.org\/10.1002\/ejp.639","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"type":"print","value":"1090-3801"},{"type":"electronic","value":"1532-2149"}],"subject":[],"published":{"date-parts":[[2014,12,8]]}}}