{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:34:12Z","timestamp":1760985252503},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EEA\/Norwegian Financial Mechanism HU 0114"},{"name":"Hungarian Academy of Science","award":["OTKA PD103964"],"award-info":[{"award-number":["OTKA PD103964"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parkinson's disease (PD) is a neurodegenerative disorder mainly marked by selective degeneration of dopaminergic neurons that leads to disabling motor and cognitive impairment. This condition is less widely appreciated as a disease associated with a substantial variety of pain syndromes, although the prevalence of pain is relatively high. Repeated painful stimulation of peripheral nerves can cause pain \u2018wind\u2010up\u2019 if the frequency of the stimulation is adequate and specifically stimulates the afferent C\u2010fibres. We presumed that in case of PD, pain or pain severeness might be frequently caused by the aggravation of the \u2018wind\u2010up\u2019 phenomenon due to any central or peripheral lesions or functional alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To test for this hypothesis, we compared three groups (patients with left\u2010 and right\u2010dominant PD and control subjects) using functional magnetic resonance imaging and thermally induced pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient showed higher average \u2018wind\u2010up\u2019 scores, compared to the healthy subjects, with lower values on the more affected sides compared to the less affected ones. In group level comparisons, patients had higher activation during \u2018wind\u2010up\u2019 compared to control subjects in two main areas; these were the posterior division of cingulate gyrus and the precuneus cortex. In case of patients, further analyses showed that applied heat pain on the less affected side elicited higher activation in the supramarginal and postcentral gyri.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These differences may arise from the deficiency in the efferent information, as well as the alterations in the central processing. It is highly likely that both processes contribute to this phenomenon simultaneously.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.659","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T21:34:54Z","timestamp":1426196094000},"page":"1288-1297","source":"Crossref","is-referenced-by-count":8,"title":["\u2018Wind\u2010up\u2019 in Parkinson's disease: A functional magnetic resonance imaging study"],"prefix":"10.1002","volume":"19","author":[{"given":"Z.","family":"Aschermann","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine University of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Neurology M\u00f3r Kaposi County Hospital Kaposv\u00e1r Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Perlaki","sequence":"additional","affiliation":[{"name":"Diagnostic Centre of P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group University of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Janszky","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine University of P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group University of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Schwarcz","sequence":"additional","affiliation":[{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group University of P\u00e9cs Hungary"},{"name":"Department of Neurosurgery Faculty of Medicine University of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine University of P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group University of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Bogner","sequence":"additional","affiliation":[{"name":"Diagnostic Centre of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Komoly","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine University of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Orsi","sequence":"additional","affiliation":[{"name":"Diagnostic Centre of P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group University of P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20629"},{"key":"e_1_2_9_3_1","volume-title":"Brodmann's: Localisation in the Cerebral Cortex","author":"Brodmann K.","year":"2006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01483-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012470999"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.4.1934"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00138-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130455.38550.9D"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_11_1","first-page":"63","article-title":"Pain in Parkinson's disease","volume":"5","author":"Ford B.","year":"1998","journal-title":"Clin Neurosci"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.120212"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.6.745"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870010106"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00051-9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01548.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01547.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074099"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-03-01756.1994"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2006.05.020"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00154-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg102"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905314106"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(66)90068-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/206097a0"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2008.145995"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22142"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn102"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182272899"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(72)90081-7"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm116"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295669.12443.d3"},{"key":"e_1_2_9_35_1","first-page":"237","article-title":"A new topographical survey of the human cerebral cortex, being an account of the distribution of the anatomically distinct cortical areas and their relationship to the cerebral sulci","volume":"41","author":"Smith G.E.","year":"1907","journal-title":"J\u00a0Anat Physiol"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10062"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.10.010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.02.002"},{"key":"e_1_2_9_39_1","volume-title":"Pain Wind\u2010up","author":"Surhone L.M.","year":"2010"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.079053"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.06.022"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.09.023"},{"key":"e_1_2_9_43_1","first-page":"379","article-title":"The myeloarchitectonics of parietal isocortex (translated from German)","volume":"18","author":"Vogt O.","year":"1911","journal-title":"J Psychol Neurol"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1704"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0931"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fejp.659","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:20:43Z","timestamp":1696285243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,12]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1002\/ejp.659"],"URL":"https:\/\/doi.org\/10.1002\/ejp.659","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,12]]}}}