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Pain intensity was assessed with an electronic visual analogue scale (<jats:styled-content style=\"fixed-case\">eVAS<\/jats:styled-content>). Numerical rating scale (<jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content>) scores of unpleasantness and temperature perception, pain\u2010drawing areas, mechanical sensitivity and pressure pain thresholds (<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>) were also measured. Participants filled out the McGill Pain Questionnaire (<jats:styled-content style=\"fixed-case\">MPQ<\/jats:styled-content>). One or two way <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>s were used for data analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Injection of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\u2010A glutamate solutions significantly increased the area under the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\u2010time curve compared with injection of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\u2010N glutamate and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010N glutamate solution (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.040). The duration of glutamate\u2010evoked pain was significantly longer when <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\u2010A glutamate was injected than when <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>\u2010N glutamate was injected (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.017). No significant effects of acidity were detected on pain drawings, <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> unpleasantness and heat perception, but there was a significant effect of acidity on <jats:styled-content style=\"fixed-case\">MPQ<\/jats:styled-content> scores and mechanical sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acidity and temperature modulate glutamate\u2010evoked jaw muscle pain suggesting an interaction between acid sensing and glutamate receptors which could be of importance for understanding clinical muscle pain conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.697","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T23:56:31Z","timestamp":1427241391000},"page":"106-115","source":"Crossref","is-referenced-by-count":5,"title":["Intramuscular pH modulates glutamate\u2010evoked masseter muscle pain magnitude in humans"],"prefix":"10.1002","volume":"20","author":[{"given":"H.","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Dentistry &amp; 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