{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:14:12Z","timestamp":1769926452628,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whole\u2010body cryotherapy (WBC) is a treatment that involves exposing the entire body to extremely cold temperatures and is used in therapeutic and sports scientific settings. Here, cryotherapy is often used to alleviate pain, but its underlying pain physiological effects are under\u2010researched. This study aims to explore whether a 3\u2010min cryochamber application results in cryo\u2010induced hypoalgesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>24 healthy male participants successfully conducted this randomised controlled crossover study consisting of a 3\u2010min WBC (cryochamber at \u221287\u00b0C) and a 3\u2010min control (ambient temperature) session. Pressure pain thresholds (PPT [Newton\/cm<jats:sup>2<\/jats:sup>]) were measured at the rectus femoris, knee joint, deltoid muscle and sternum pre and post0, post5, post15 and post30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results revealed a significant \u2018condition\u2019\u2009\u00d7\u2009\u2018time\u2019 interaction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup><jats:sub>partial<\/jats:sub>\u2009=\u20090.280) for PPT<jats:sub>Total<\/jats:sub> (pooled for one average value) with hypoalgesia observed after WBC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; pre: 77.0\u2009\u00b1\u200917.2, post0: 89.6\u2009\u00b1\u200918.6, post5: 83.6\u2009\u00b1\u200919.4, post15: 83.1\u2009\u00b1\u200918.2, post30: 80.8\u2009\u00b1\u200917.7) and no change following the control (<jats:italic>p<\/jats:italic>\u2009=\u20090.873; pre: 75.1\u2009\u00b1\u200918.8, post0: 75.3\u2009\u00b1\u200919.4, post5: 74.6\u2009\u00b1\u200919.2, post15: 75.7\u2009\u00b1\u200919.3, post30: 75.3\u2009\u00b1\u200919.1). The same pattern was observed for individual landmarks. Between\u2010group differences were consistently observed, with higher values following the WBC. No significant \u2018time\u2019\u2009\u00d7\u2009\u2018intervention\u2019\u2009\u00d7\u2009\u2018landmark\u2019 interaction effect (<jats:italic>p<\/jats:italic>\u2009=\u20090.439) was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that a three\u2010minute cryochamber exposure induces robust hypoalgesia in healthy participants, as indicated by increased PPT, lasting up to 30\u2009min but gradually declining over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance Statement<\/jats:title><jats:p>Whole\u2010body cryotherapy significantly induces short\u2010term hypoalgesia, with increased mechanical pain thresholds lasting up to 30 minutes. Compared to ambient temperature, cryotherapy provided greater pain relief across multiple body landmarks, with 82.6% of participants experiencing hypoalgesia. These findings highlight the potential of cryotherapy for pain management and support further research on its long\u2010term efficacy and clinical applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.70017","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T17:52:19Z","timestamp":1743875539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cryo\u2010Induced Hypoalgesia: The Effects of an Acute Cryochamber Exposure on Pain Perception\u2014A Randomised Controlled Cross\u2010Over Trial"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1738-4891","authenticated-orcid":false,"given":"Fabian","family":"Tomschi","sequence":"first","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cegla","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine Helios University Hospital Wuppertal  Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-2526","authenticated-orcid":false,"given":"Thomas","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Wuppertal 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