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The effective management of pain by adults with SCD influences their health outcomes. Opioids remain essential for most pain syndromes, but non\u2010pharmacological interventions are preferred for daily pain due to the risk of addiction. However, their effectiveness is variable. Understanding the underlying processes associated with pain is crucial for developing more effective non\u2010pharmacological strategies. This study aimed to enhance comprehension of the pain mechanisms in SCD to identify potential areas of action for effective non\u2010pharmacological interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>An evaluation was conducted on the severity and interference of pain, pain\u2010related cognitions and emotions. We used network analysis to simultaneously examine the intricate relationships between these variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A pain intensity exceeding 4 at a steady state distinguishes a subgroup at elevated risk of negative pain\u2010related emotions and cognitions. The network analysis revealed intricate interconnections, with three distinct subgroups of variables mimicking the Neuromatrix model (cognitive\u2010evaluative, motivational\u2010affective and sensory\u2010discriminative subgroups). The derived directed acyclic graph suggests potential mechanisms between these three subgroups, with catastrophising having a pivotal role.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study extends previous research by providing a comprehensive network analysis of pain\u2010related variables in SCD, offering novel insights into the complex interplay between pain experience, cognitions and emotions. These findings have important clinical implications, as they suggest that targeting dysfunctional pain cognitions and\/or negative emotions may be beneficial for improving pain management and quality of life in SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This study was the first to use network analyses to understand simultaneously multiple relationships between variables referring to pain, and pain\u2010related negative emotions and cognitions in adults with SCD. Findings, providing support to the Neuromatrix model, offer novel insight to better understand pain and the associated negative emotions and cognition in SCD. The derived directed acyclic graph explored potential underlying psychological processes associated with pain that could be specifically targeted by future effective psychological interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70059","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T07:19:24Z","timestamp":1749799164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering Pain Experience in Adult Patients With Sickle Cell Disease: A Network Analysis of Pain\u2010Related Factors in a Single French Sickle Cell Centre"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-7251","authenticated-orcid":false,"given":"D.","family":"Oudin Doglioni","sequence":"first","affiliation":[{"name":"Laboratoire Interuniversitaire de Psychologie\/Personnalit\u00e9, Cognition, Changement Social (LIP\/PC2S) Universit\u00e9 Grenoble Alpes, Universit\u00e9 Savoie Mont\u2010Blanc  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-082X","authenticated-orcid":false,"given":"M.","family":"Couette","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Teaching Hospital Henri Mondor  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2434-9234","authenticated-orcid":false,"given":"S.","family":"Fort\u00e9","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Haematology, Department of Medicine Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2029-8126","authenticated-orcid":false,"given":"F.","family":"Galacteros","sequence":"additional","affiliation":[{"name":"Red Blood Cell Genetic Diseases Unit (UMGGR) Teaching Hospital Henri Mondor  Cr\u00e9teil France"},{"name":"French National Referral Centre for Sickle Cell Disease (MCGRE)  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6670-7074","authenticated-orcid":false,"given":"M.\u2010C.","family":"Gay","sequence":"additional","affiliation":[{"name":"EA4430 EvaCliPsy Paris Nanterre University  Nanterre France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001916.pub3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204701004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20600"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90005-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2433"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2006.09.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S151198"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2020.102327"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-383430"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2167702616628523"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2018.12.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/17423953060020011101"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010050212\u2010185608"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/met0000479"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000446"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.01.157"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsh021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/asn034"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2301143"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007600"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.02.008"},{"key":"e_1_2_9_23_1","unstructured":"Cleeland C. andK. 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