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The sample included 22,864 individuals: 5716 with acute back pain, 5716 with chronic back pain, and 11,432 pain\u2010free controls. Group comparisons were performed using network analysis and analysis of covariance, adjusted for socioeconomic deprivation, body mass index, smoking, and alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Well\u2010being was poorer in acute (mean difference [95% CI]: 0.20 [0.14, 0.25] points; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and chronic back pain (0.39 [0.34, 0.45] points; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) compared to controls. More stressful life events were measured in acute (0.03 [0.01, 0.05] points; <jats:italic>p<\/jats:italic>\u2009=\u20090.041) and chronic back pain (0.03 [0.01, 0.05] points; <jats:italic>p<\/jats:italic>\u2009=\u20090.028) compared to controls. However, this finding was not robust to sensitivity analyses. Elevated CRP was found in acute (2.28 [0.57, 3.99]%; <jats:italic>p<\/jats:italic>\u2009=\u20090.024; ES\u2009=\u2009very small), but not in chronic back pain, compared to controls. No significant group differences were observed for physical activity. Network structures did not differ between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Differences in well\u2010being and CRP among pain\u2010free, acute, and chronic back pain individuals were identified, suggesting that variables may be affected by back pain temporality. Further prospective research incorporating additional variables is needed to explore the drivers of back pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance Statement<\/jats:title><jats:p>Individuals with acute back pain showed 2% higher CRP than controls, though values remained within the normal range (&lt;\u20095\u2009mg\/L) across groups and below clinical relevance, suggesting limited utility of CRP in distinguishing acute from chronic back pain. Poorer well\u2010being in both acute and chronic back pain underscores the need to explore underlying causal pathways. Moreover, similar network structures among groups indicate no neuroimmune involvement in back pain onset or chronification based on the variables examined.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ejp.70079","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T04:18:38Z","timestamp":1753071518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Well\u2010Being, Inflammation, and Physical Activity in Acute and Chronic Back Pain: A Cross\u2010Sectional Analysis of 22,864 <scp>UK<\/scp> Biobank Participants"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8781-9327","authenticated-orcid":false,"given":"Romina","family":"Gollan","sequence":"first","affiliation":[{"name":"Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-9375","authenticated-orcid":false,"given":"Patrick J.","family":"Owen","sequence":"additional","affiliation":[{"name":"Eastern Health Emergency Medicine Program  Melbourne Victoria Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-9430","authenticated-orcid":false,"given":"Jamie L.","family":"Tait","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-9466","authenticated-orcid":false,"given":"Luana C.","family":"Main","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences Deakin University  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa473"},{"key":"e_1_2_10_3_1","unstructured":"Alperovitch\u2010Najenson D. 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