{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:33:13Z","timestamp":1785515593968,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PZ00P3_216468"],"award-info":[{"award-number":["PZ00P3_216468"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Central post stroke pain (CPSP) is attributed to vascular lesions of the central somatosensory system, including the thalamus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A better characterisation of clinical findings in patients with CPSP after thalamic stroke can facilitate research and treatment of this refractory pain syndrome. We aimed to quantify somatosensory abnormalities in CPSP patients after thalamic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixteen patients with CPSP after thalamic stroke, 14 patients with a history of thalamic stroke without any pain (stroke control patients, SCP) and 12 healthy controls (HC) underwent detailed clinical examination, standardised quantitative sensory testing (QST) and a pain questionnaire. QST results were compared to age and sex adjusted reference data to obtain\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores. Group comparisons were performed with one\u2010way analysis of variance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Temperature perception did not differ in CPSP patients, apart from thermal sensory limen (higher in CPSP vs. HC but no difference vs. SCP). Patients with CPSP showed higher mechanical detection thresholds compared to SCP (\u0394\u2009=\u20091.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017, no difference vs. HC) and they were more sensitive to mechanical pain than SCP (lower mechanical pain thresholds vs. SCP: \u0394\u2009=\u2009\u22121.32,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014, no difference vs. HC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results indicate somatosensory abnormalities in patients with CPSP after thalamic stroke, associated with the perception of mechanical stimuli. A short somatosensory screening including mechanical perception may contribute to an accurate diagnosis of this debilitating condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      Thalamic CPSP is very rare, thus our data contribute to the clinical and sensory phenotyping of patients suffering from this debilitating condition. We did not find abnormalities in\n                      <jats:italic>thermal<\/jats:italic>\n                      measures, but only\n                      <jats:italic>mechanical<\/jats:italic>\n                      thresholds in our cohort, suggesting that not only changes in temperature perception are necessary for the development of pain after thalamic stroke. Our findings suggest that a short QST protocol including\n                      <jats:italic>mechanical<\/jats:italic>\n                      testing using von Frey filaments and pin\u2010prick\u2010stimulators may be useful in the diagnosis of thalamic CPSP.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70104","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T10:31:46Z","timestamp":1755253906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Somatosensory Profile of Central Post Stroke Pain of Thalamic Origin: Findings of a Quantitative Sensory Testing Study"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1932-227X","authenticated-orcid":false,"given":"Kristel","family":"Berati","sequence":"first","affiliation":[{"name":"Clinic of Neurology University and University Hospital of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-2142","authenticated-orcid":false,"given":"Lukas","family":"Enz","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priska","family":"Zuber","sequence":"additional","affiliation":[{"name":"Health, Medical and Neuropsychology Institute of Psychology, Leiden University  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina Alexandra","family":"Ebner","sequence":"additional","affiliation":[{"name":"Clinic of Neurology University and University Hospital of Basel  Basel Switzerland"},{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaumiya","family":"Sellathurai","sequence":"additional","affiliation":[{"name":"Clinic of Neurology University and University Hospital of Basel  Basel Switzerland"},{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kean","family":"Schoenholzer","sequence":"additional","affiliation":[{"name":"Clinic of Neurology University and University Hospital of Basel  Basel Switzerland"},{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico Burguet","family":"Villena","sequence":"additional","affiliation":[{"name":"Clinic of Neurology University and University Hospital of Basel  Basel Switzerland"},{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gaetano","sequence":"additional","affiliation":[{"name":"Novartis  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Kappos","sequence":"additional","affiliation":[{"name":"Department of Clinical Research University Hospital Basel and University of Basel  Basel Switzerland"},{"name":"Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB) University Hospital Basel and University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Magon","sequence":"additional","affiliation":[{"name":"Pharma Research and Early Development, Neuroscience and Rare Diseases Roche Innovation Center Basel F. 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