{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:21:04Z","timestamp":1790364064542,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Neuropathic pain (NeP) is a common and debilitating consequence of several neurological conditions. Gabapentinoids are used on a large scale for the treatment of both central and peripheral NeP. Mirogabalin, a novel gabapentinoid, has been proposed as a promising treatment for this condition; however, its efficacy and safety profile still need to be determined in clinical practice. In this systematic review and meta\u2010analysis, we assessed the efficacy on pain intensity reduction, effects on sleep interference by pain, and safety of mirogabalin compared with placebo in patients affected by NeP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Databases and Data Treatment<\/jats:title>\n                    <jats:p>\n                      We searched PubMed, Cochrane Library, Embase, Web of Science, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      databases for randomised controlled trials (RCTs) comparing mirogabalin with placebo in patients experiencing central or peripheral NeP. We computed mean differences (MD) and pooled risk ratios (RR) for continuous and binary outcomes, respectively, with 95% confidence intervals (CI). Pain was measured on a 0 to 10 numerical rating scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 6 RCTs involving 3048 patients. The mean age was 60.6\u2009years, and 64.7% were male. When compared with placebo, patients treated with mirogabalin had a significant decrease in average daily pain (MD \u22120.60; 95% CI \u22120.75 to \u22120.45;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and in pain\u2010related sleep interference scores (MD \u22120.66; 95% CI \u22120.81 to \u22120.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mirogabalin group showed a higher rate of substantial pain relief (\u2265\u200950%) compared with the placebo group (RR 1.27; 95% CI 1.10 to 1.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Nonetheless, treatment with mirogabalin increased the risk of weight gain, peripheral oedema, somnolence and dizziness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this meta\u2010analysis of RCTs evaluating patients with central and peripheral NeP, mirogabalin significantly improved pain and decreased sleep interference by pain, as compared with placebo; however, there was an increased risk of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This meta\u2010analysis refines the current understanding of mirogabalin by demonstrating modest yet consistent benefits in reducing pain and pain\u2010related sleep interference across neuropathic pain syndromes. The results contribute to ongoing efforts to optimise neuropathic pain management and provide more robust evidence to support clinical decision\u2010making and guideline development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70112","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:36:54Z","timestamp":1758278214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mirogabalin for Treatment of Neuropathic Pain and Associated Sleep Interference: An Updated Meta\u2010Analysis"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-2090","authenticated-orcid":false,"given":"Rafael Batista","family":"Jo\u00e3o","sequence":"first","affiliation":[{"name":"Neurology and Neurophysiology Department Goi\u00e2nia Neurological Institute  Goi\u00e2nia Goi\u00e1s Brazil"},{"name":"Division of Neurology, Department of Internal Medicine S\u00e3o Vicente de Paulo Charity Hospital  Jundia\u00ed S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilly Octoria","family":"Tagore Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Indonesia  Depok Wijaya Karya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Batista","family":"Jo\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Jos\u00e9 Alencar City Hospital  S\u00e3o Bernardo do Campo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa Mendes","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julyana Medeiros","family":"Dantas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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