{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:30:06Z","timestamp":1791498606976,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain catastrophising is a maladaptive cognitive\u2013emotional trait linked to greater pain severity and poorer outcomes, yet its neurophysiological correlates remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We tested whether pain catastrophising amplifies cortical responses to nociceptive input, independent of subjective pain intensity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010two healthy adults underwent EEG during painful laser stimulation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009= 29; mean age 24.3 \u00b1 10.9 years; 55.2% female) or non\u2010painful electrical stimulation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009= 23; mean age 23.3 \u00b1 8.5 years; 56.5% female). Each trial comprised a triplet of stimuli (S1, S2, S3) with a 1.5\u2010s interstimulus interval; 30 triplets were delivered per modality. Associations between Pain Catastrophising Scale (PCS) scores and amplitudes of laser\u2010evoked potentials (LEP\u2010N2P2) and somatosensory\u2010evoked potentials (SEP\u2010N1P2) were tested using mixed\u2010effects models, with trial\u2010level pain ratings as a covariate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher PCS scores were associated with greater LEP\u2010N2P2 amplitude for the first stimulus (S1) in the painful condition, independent of pain ratings, at the parietal midline electrode (Pz). No associations were observed between PCS and SEP\u2010N1P2 in the non\u2010painful condition, or between PCS and early N1 components of LEP or SEP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pain catastrophising selectively amplifies later\u2010stage cortical responses to painful stimuli, strongest at first presentation (S1) and localised to parietal Pz channel, with no effects in non\u2010painful controls stimulation modality. These findings support LEPs as mechanistic biomarkers of catastrophising\u2010related vulnerability. Combined with psychological assessment, such markers could improve early screening, risk stratification, and personalised interventions targeting maladaptive salience and attentional processes in pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Pain catastrophising was associated with amplified laser\u2010evoked potential (LEP\u2010N2P2) responses during painful, but not non\u2010painful, stimulation in healthy adults. The effect was localised to the parietal midline, strongest for the first stimulus in a sequence, and diminished with repetition. These findings suggest modality\u2010dependent cortical modulation and highlight LEP\u2010N2P2 as a potential neural marker of maladaptive pain processing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70117","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T12:02:22Z","timestamp":1757073742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pain Catastrophising Amplifies Parietal Responses to Painful Laser Stimulation in Healthy Controls"],"prefix":"10.1002","volume":"29","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Realyvasquez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Finan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Quigg","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Moosa","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Jeffrey","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-739X","authenticated-orcid":false,"given":"Chang\u2010Chia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of Virginia School of Medicine  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2","article-title":"Package \u2018lme4\u2019","volume":"12","author":"Bates 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