{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:56:02Z","timestamp":1790168162723,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic low back pain (cLBP) is extremely common and is one of the Chronic Overlapping Pain Conditions (COPCs), 10 conditions thought to have similar underlying pathophysiology. Little is known about the prevalence and co\u2010occurrence of cLBP with other commonly accepted conditions referred to as COPCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed participants enrolled in a pragmatic trial of mindfulness\u2010based stress reduction for cLBP to determine the prevalence of co\u2010occurring COPCs using a validated COPC screener. We compared psychosocial and physical functioning among participants with only cLBP and participants with cLBP and additional COPCs using Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, chi\u2010squared tests and multivariable linear regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 285 enrollees (age range: 18\u201388\u2009years, mean age: 52.2\u2009years, SD\u2009=\u200915.3), 272 (95%) reported pain outside the upper and lower back region. One hundred and twenty\u2010nine people (45%) had one COPC, and 68 (24%) had two or more COPCs not including cLBP. The most common COPCs were irritable bowel syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956, 20%); myalgia encephalomyelitis\/chronic fatigue syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200954, 19%); and fibromyalgia (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942, 15%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found strong differences when comparing people with cLBP alone to those with cLBP and COPCs. People with COPCs reported more pain symptoms, higher levels of anxiety, depression, fatigue and scored worse across measures of physical functioning and pain symptoms. An additional COPC was associated with a 7.6\u2010point increase in fatigue scores (95% CI: 5.6, 9.7) on a T\u2010score metric (mean\u2009=\u200950, SD\u2009=\u200910).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Compared to people with low back pain alone, individuals with additional chronic pain experienced more severe pain symptoms, more anxiety, depression and fatigue. In this sample of people with cLBP, overlapping pain conditions were common, affecting 45% of people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration Number and Registry Name<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      identifier NCT04129450.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70119","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:24:50Z","timestamp":1756797890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of Chronic Overlapping Pain Conditions in Participants With Chronic Low Back Pain Enrolled in a Pragmatic Trial of Mindfulness\u2010Based Stress Reduction"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3537-649X","authenticated-orcid":false,"given":"Vanessa Eve","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Department of Biostatistics, Gillings School of Global Public Health University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3360-4217","authenticated-orcid":false,"given":"Jessica","family":"Barnhill","sequence":"additional","affiliation":[{"name":"Program on Integrative Medicine, Department of Physical Medicine and Rehabilitation University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3078-2918","authenticated-orcid":false,"given":"Carol M.","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Physical Therapy University of Pittsburgh School of Medicine and School of Health and Rehabilitation Sciences  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Family Medicine University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"},{"name":"Piedmont Health Services at Siler City Community Health Center  Siler City North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tra P.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA"},{"name":"Center for Mindfulness and Compassion, Cambridge Health Alliance, Department of Family Medicine and Community Health University of Massachusetts Medical School  Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-000X","authenticated-orcid":false,"given":"Paula","family":"Gardiner","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Community Health University of Massachusetts Medical School  Worcester Massachusetts USA"},{"name":"Department of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-7821","authenticated-orcid":false,"given":"Keturah R.","family":"Faurot","sequence":"additional","affiliation":[{"name":"Program on Integrative Medicine, Department of Physical Medicine and Rehabilitation University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-9633","authenticated-orcid":false,"given":"Susan","family":"Gaylord","sequence":"additional","affiliation":[{"name":"Program on Integrative Medicine, Department of Physical Medicine and Rehabilitation University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-0061","authenticated-orcid":false,"given":"Janice M.","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly N.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Boston University Chobanian &amp; 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