{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:25:29Z","timestamp":1791761129899,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["GR\u20102016\u201002363848"],"award-info":[{"award-number":["GR\u20102016\u201002363848"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Although robust genetic markers for episodic migraine (EM) have been identified, variants associated with chronic migraine (CM) are still unknown. Given the potential pathophysiologic overlap between EM and CM, we investigated whether six single nucleotide polymorphisms (SNPs), robustly associated with EM susceptibility (\n                      <jats:italic>LRP1<\/jats:italic>\n                      rs11172113,\n                      <jats:italic>PRDM16<\/jats:italic>\n                      rs10797381,\n                      <jats:italic>FHL5<\/jats:italic>\n                      rs7775721,\n                      <jats:italic>TRPM8<\/jats:italic>\n                      rs10166942, near\n                      <jats:italic>TSPAN2<\/jats:italic>\n                      rs2078371 and\n                      <jats:italic>MEF2D<\/jats:italic>\n                      rs1925950) also play a role in the risk of developing CM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 200 EM and 202 CM participants were prospectively included. Genotyping of selected SNPs was performed by TaqMan real\u2010time PCR in 192 individuals with EM and 198 with CM who consented to genetic analysis. A validation group of 312 healthy individuals was used. Genetic associations were assessed by logistic regression using dominant, recessive, and allelic models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In multivariable logistic regression analysis,\n                      <jats:italic>LRP1<\/jats:italic>\n                      rs11172113 T&gt;C and (near)\n                      <jats:italic>TSPAN2<\/jats:italic>\n                      rs2078371 T&gt;C were nominally associated with CM. However, only the association for\n                      <jats:italic>LRP1<\/jats:italic>\n                      rs11172113 survived Bonferroni correction, with carriers of the minor C allele (genotypes T\/C or C\/C) having a lower risk of CM compared to wild\u2010type homozygous subjects (OR: 0.38; 95% CI: 0.20\u20130.71;\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value: 0.0025). This protective effect was also observed in the analysis comparing CM participants with healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Carriers of the minor allele of\n                      <jats:italic>LRP1<\/jats:italic>\n                      rs11172113 have a reduced risk of CM. However, further large\u2010scale studies, ideally with a multicentre design, are warranted to confirm the association between\n                      <jats:italic>LRP1<\/jats:italic>\n                      rs11172113 and CM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>\n                      This study identified an association between the minor allele of\n                      <jats:italic>LRP1<\/jats:italic>\n                      rs11172113 (low\u2010density lipoprotein receptor\u2010related protein 1, a receptor with key roles in lipid metabolism, vascular integrity, and inflammation control) and a reduced risk of chronic migraine. These findings support the hypothesis that episodic and chronic migraine share genetic risk factors and suggest a potential protective role for this variant.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70120","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T10:08:17Z","timestamp":1757066897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Association of Migraine Susceptibility SNPs With the Risk of Chronic Migraine"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-7817","authenticated-orcid":false,"given":"Sarah","family":"Cargnin","sequence":"first","affiliation":[{"name":"Department of Health Sciences Universit\u00e0 del Piemonte Orientale (UPO)  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Giacon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Piemonte Orientale \u2018A. Avogadro\u2019  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Del Corona","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Universit\u00e0 del Piemonte Orientale (UPO)  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Zanaboni","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Facchetti","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De Icco","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Vaghi","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Sances","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascia","family":"Ghiotto","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Guaschino","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Greco","sequence":"additional","affiliation":[{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tassorelli","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences University of Pavia  Pavia Italy"},{"name":"Headache Science and Neurorehabilitation Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Terrazzino","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Piemonte Orientale \u2018A. 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