{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:43:33Z","timestamp":1772995413723,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study investigates the association of sociodemographic factors and comorbidities with labour market affiliation among patients with non\u2010malignant chronic pain treated at multidisciplinary pain centres in Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This registry\u2010based cohort study used data from the nationwide Danish Civil Registration System and Danish National Patient Registry. Patients treated at multidisciplinary pain centres in 2013\u20132017 were included. Labour market affiliation was assessed 5\u2009years before and 2\u2009years after treatment and at treatment initiation (baseline). Sequence and logistic regression analyses were used to identify associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      2375 patients (median age 47\u2009years, female 64%, comorbidity: Mean Charlson's comorbidity score: 0.88, affective disorder: 45%, anxiety disorder: 37.0%, personality disorder: 7.8%) were included. At treatment initiation, only 34.2% of patients were employed, compared to 58.6% 5\u2009years before treatment. Sequence analysis revealed that most patients remained in or transitioned to a \u2018no labour market affiliation\u2019 state. Factors significantly associated with labour market affiliation across timepoints included age (adjusted odd ratio [aOR] and 95% confidence interval [CI]\n                      <jats:sub>age 56\u201365<\/jats:sub>\n                      \u2009=\u20090.51 [0.38\u20130.69]), marital status (aOR\n                      <jats:sub>cohabitant<\/jats:sub>\n                      \u2009=\u20091.58 [1.30\u20131.92]), education level (aOR\n                      <jats:sub>high<\/jats:sub>\n                      \u2009=\u20094.56 [3.51\u20135.93]), immigrant status (aOR\n                      <jats:sub>non\u2010western<\/jats:sub>\n                      \u2009=\u20090.35 [0.26\u20130.45]) and psychiatric comorbidities (aOR\n                      <jats:sub>affective disorders<\/jats:sub>\n                      \u2009=\u20090.67 [0.56\u20130.87]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with high\u2010impact, treatment\u2010resistant chronic pain face early labour market detachment, highlighting the need for timely, equitable interventions to support employment, especially among vulnerable groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>The study offers new evidence on how socioeconomic and psychiatric comorbid vulnerabilities shape long\u2010term labour market affiliation before relevant multidisciplinary treatment is initiated and suggests that key intervention opportunities for at\u2010risk patients may be missed under current practice.<\/jats:p>\n                  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