{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:37:40Z","timestamp":1789202260335,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Graded Chronic Pain Scale\u2010Revised (GCPS\u2010R) framework enables a standardised measure of disease severity and was incorporated into the national disease surveillance in Denmark in 2023. Novel dose\u2013response associations between GCPS\u2010R\u2010systemised disease severity, general health, well\u2010being, and modifiable lifestyle behaviour were analysed to enhance awareness of risk associations related to chronic non\u2010cancer pain disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study including 8329 non\u2010cancer participants aged 16\u2009years and older from the Danish National Health Survey 2023. The participants completed a comprehensive self\u2010reported questionnaire on general health, well\u2010being, and modifiable lifestyle behaviour, including the GCPS\u2010R framework. Multivariate\u2010adjusted odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using logistic regression models for dichotomous outcomes related to general health, well\u2010being, and modifiable lifestyle behaviour adjusted for sex, age, area of residence, BMI, country of origin, education and marital status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The GCPS\u2010R score had strong positive dose\u2013response associations with odds of poor\/fair general health, showing ORs 1.66 (95% CI: 1.32\u20132.10) in mild\u2010impact, 6.08 (5.02\u20137.37) in bothersome\u2010impact, and 13.53 (11.53\u201315.88) in high\u2010impact compared with no chronic non\u2010cancer pain. The GCPS\u2010R score had overall strong positive associations with odds of poor well\u2010being outcomes and moderate positive associations with odds of unhealthy modifiable lifestyle behaviour outcomes concerning illicit drugs, obesity, sedentary lifestyle, unhealthy diet and tobacco.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The GCPS\u2010R framework is applicable in national surveys enabling graded measures for associations related to chronic non\u2010cancer pain disease severity. Unified cross\u2010country strategies for national surveillance could strengthen the evidence base for equitable public health policies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Chronic non\u2010cancer pain is a highly prevalent disease associated with elevated risks of several bio\u2010 psychosocial health conditions. However, whether risks related to chronic non\u2010cancer pain vary by disease severity is currently unknown. Hellmann et\u00a0al. found the validated GCPS\u2010R framework useful in national survey\u2010based disease surveillance. The GCPS\u2010R\u2010systemised disease severity measures classified in no, low\u2010impact, bothersome\u2010impact, and high\u2010impact chronic non\u2010cancer pain enabled nuanced knowledge about such risk associations, being a fundamental base in planning targeted healthcare strategies for improved chronic non\u2010cancer pain management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70138","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:19:21Z","timestamp":1759825161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations of Graded Chronic Non\u2010Cancer Pain Severity With Well\u2010Being and Modifiable Lifestyle Behaviour: Findings From a Danish Population\u2010Based Cross\u2010Sectional Survey"],"prefix":"10.1002","volume":"29","author":[{"given":"Sophie Sell","family":"Hellmann","sequence":"first","affiliation":[{"name":"National Institute of Public Health University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Bjarke","family":"Vaegter","sequence":"additional","affiliation":[{"name":"Pain Research Group, Pain Center, Department of Anesthesiology and Intensive Care Medicine University Hospital Odense  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Handberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille Lykke","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Copenhagen University Hospital Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geana Paula","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Anaesthesiology Pain and Respiratory Support, Pain and Palliative Care Research Group, Multidisciplinary Pain Centre, University Hospital Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Oncology Section of Palliative Medicine, University Hospital Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Sj\u00f8gren","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"St. Luke's Academy of Palliative Medicine, St. Lukes Foundation  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lau Caspar","family":"Thygesen","sequence":"additional","affiliation":[{"name":"National Institute of Public Health University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Ekholm","sequence":"additional","affiliation":[{"name":"National Institute of Public Health University of Southern Denmark  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040949"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3310\/MKRT2948"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001311"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6736a2"},{"key":"e_1_2_11_9_1","unstructured":"Danish Health Authority.2022.\u201c10\u20104\u2014The Danish Health Authority Announces New Low\u2010Risk Drinking Guidelines. 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