{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:39:59Z","timestamp":1788295199984,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic disrupted healthcare systems worldwide, including the postponement of non\u2010urgent care and reallocation of resources toward COVID\u201019 patients. The aim of this study was to assess the impact of the first Dutch COVID\u201019 lockdown on the initiation of new analgesic prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analysed dispensing data from 1890 Dutch pharmacies, covering approximately 96% of the population (5.46\u2009million patients). The number of first\u2010time prescription analgesics dispensed (ATC2 N02 class, e.g., opioids, anilides) was compared between the first halves of 2019 and 2020. First\u2010time users were defined as patients who had not received the drug in the preceding year. Data were stratified by age group (children, adolescents, adults, elderly), sex and time periods: weeks 1\u201311 (pre\u2010lockdown 2020), 12\u201319 (lockdown) and 20\u201326 (post\u2010lockdown).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total number of first\u2010time dispensed analgesic drugs was significantly lower in 2020 (367,094) than in 2019 (388,973,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), with a notable reduction occurring during the lockdown period (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). Significant declines in first\u2010time dispensed analgesic drugs were observed among adolescents and adults during lockdown (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), particularly among females. In contrast, no significant changes were found among children and the elderly. The number of first\u2010time dispensed analgesic drugs during the pre\u2010 and post\u2010lockdown periods was comparable between the 2\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Delayed healthcare during the lockdown was associated with a decrease in first\u2010time dispensed analgesic drugs, especially among adolescents and adults. This may indicate untreated pain or increased reliance on over\u2010the\u2010counter alternatives during this period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This Nationwide Dutch study showed a significant decline in first\u2010time dispensed analgesic drugs during the first lockdown period of the COVID\u201019 pandemic, especially among adolescents and adults. This may indicate untreated pain due to delayed healthcare or an increased reliance on over\u2010the\u2010counter alternatives during this period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70139","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:39:51Z","timestamp":1759300791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Significant Decline in the Number of Newly Dispensed Analgesics During the First\n                    <scp>COVID<\/scp>\n                    \u201019 Lockdown in The Netherlands"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8909-4073","authenticated-orcid":false,"given":"Maureen N.","family":"Zijlstra","sequence":"first","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3073-9749","authenticated-orcid":false,"given":"Pantea","family":"Kiani","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-4432","authenticated-orcid":false,"given":"Pauline A.","family":"Hendriksen","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2742-907X","authenticated-orcid":false,"given":"Dana M.","family":"Dijkgraaf","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8678-9182","authenticated-orcid":false,"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht the Netherlands"},{"name":"Danone Global Research and Innovation Center  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-2096","authenticated-orcid":false,"given":"Joris C.","family":"Verster","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht the Netherlands"},{"name":"Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine TU Dresden  Dresden Germany"},{"name":"Centre for Mental Health and Brain Sciences Swinburne University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Bos N. 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