{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:43:25Z","timestamp":1772995405184,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pain (CP) in older adults was associated with depression in numerous cross\u2010sectional studies. However, the longitudinal link between CP characteristics and depressive symptoms in this population remains unsettled. We aimed to assess the prospective link between CP intensity and long\u2010term depressive symptoms in a population\u2010based cohort of older participants, considering numerous potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study sample was gathered from the PAQUID study, a prospective cohort study of community\u2010dwellers above 65. Information regarding CP characteristics was collected at the 3\u2010year follow\u2010up visit. The sample included the 742 participants who fulfilled this CP questionnaire. Three CP groups were distinguished: no (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009504), mild (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009101), and intense (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009137) CP. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression scale (CES\u2010D) every 2\u20133\u2009years during 12\u2009years (6 waves). The association between CP and the 12\u2010year CES\u2010D course (12\u2009years after the 3\u2010year visit) was investigated using a multivariate latent process mixed model for curvilinear data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the participants without CP, those with moderate and intense CP had significantly higher CES\u2010D levels at baseline with a dose\u2013response relationship as a function of pain intensity (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.366,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0308; 0.607,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001, respectively). However, the time course was comparable in the three groups (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009= \u22120.003,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8351; \u22120.003,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.8516, for mild and intense CP, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CP intensity is associated with higher levels of depressive symptoms persisting throughout the long period of follow\u2010up. This finding reinforces the importance of early treatment of CP in older adults to prevent its sustainable psychological consequences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Depression and chronic pain (CP) have been frequently associated in older adults. The longitudinal relationship between CP characteristics and the long\u2010term course of depressive symptoms in this population has yet to be specified. The present results showed that CP intensity is associated with higher levels of depressive symptoms persisting throughout a 15\u2010year follow\u2010up period, with a dose\u2013response relationship. This finding reinforces the importance of early treatment of CP in the older population, in order to prevent its lasting psychological consequences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70159","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:52:50Z","timestamp":1762282370000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baseline Chronic Pain Intensity and Long\u2010Term Depressive Symptoms in French Older Community\u2010Dwelling Adults: A 12\u2010Year Prospective Cohort Study"],"prefix":"10.1002","volume":"29","author":[{"given":"Isabelle","family":"Rouch","sequence":"first","affiliation":[{"name":"Memory Clinical and Research Center of Saint Etienne (CMRR) Neurology Unit, University Hospital of Saint Etienne  Saint Etienne France"},{"name":"INSERM, U1219, Bordeaux Population Health Center University of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Koleck","sequence":"additional","affiliation":[{"name":"INSERM, U1219, Bordeaux Population Health Center University of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arlette","family":"Edjolo","sequence":"additional","affiliation":[{"name":"Memory Clinical and Research Center of Saint Etienne (CMRR) Neurology Unit, University Hospital of Saint Etienne  Saint Etienne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Peres","sequence":"additional","affiliation":[{"name":"INSERM, U1219, Bordeaux Population Health Center University of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Laurent","sequence":"additional","affiliation":[{"name":"INSERM, U1028, CNRS, UMR5292, Neuropain Team, Lyon Neuroscience Research Center  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Michel","family":"Dorey","sequence":"additional","affiliation":[{"name":"Aging Psychiatry Unit, CH le Vinatier  Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Dartigues","sequence":"additional","affiliation":[{"name":"INSERM, U1219, Bordeaux Population Health Center University of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Amieva","sequence":"additional","affiliation":[{"name":"INSERM, U1219, Bordeaux Population Health Center University of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.10.041"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.2013.Diagnostic and Statistical Manual of Mental Disorders.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.02.012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/096382800296665"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.850"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2022.103417"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.12.013"},{"key":"e_1_2_11_10_1","first-page":"1","article-title":"Pain Interference and Depressive Symptom Severity Across 10\u2009Years in Individuals With Long\u2010Term Spinal Cord Injury","volume":"48","author":"Clark J. 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