{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:01Z","timestamp":1786977661680,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Central modulatory pain mechanisms may influence improvements after exercise in low back pain (LBP). This observational study explored whether temporal summation of pain (TSP) and exercise\u2010induced hypoalgesia (EIH) are associated with improvements in resting pain and movement\u2010evoked pain, as it may improve the understanding of variation in effectiveness after an exercise program in individuals with LBP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>At baseline and after an 8\u2010week exercise program, ratings of resting pain and movement\u2010evoked pain on a 0\u201310 numerical rating scale (NRS) were assessed in 69 individuals with LBP. Cuff algometry at the lower leg (recording of the pain intensity to 10 repeated painful cuff stimulation) and pressure pain thresholds at the low back and leg immediately before and after a 6\u2010min walking test were used to assess baseline TSP and EIH, respectively. Linear regression analyses adjusted for age and gender were used to assess the strength and direction of associations between baseline TSP and EIH with pain improvements (baseline minus Week 8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Resting\u2010pain NRS scores were reduced by 0.9 (0.5\u20131.3) and movement\u2010evoked pain by 0.9 (0.4\u20131.5) after 8\u2009weeks of exercise. Higher baseline TSP was associated with improvement in resting pain (\n                      <jats:italic>B<\/jats:italic>\n                      \u2009=\u20090.29,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), but not significantly with improvement in movement\u2010evoked pain. Baseline EIH, regardless of the site point, was not significantly associated with resting or movement\u2010evoked pain improvements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that higher TSP at baseline is weakly but significantly associated with larger improvement in resting\u2010pain intensity after an 8\u2010week exercise program in people with LBP but this should be confirmed in larger studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Assessing central pain mechanisms may help identify individuals more likely to benefit from therapy, guiding personalised exercise\u2010based treatments. Thus, this exploratory study provides preliminary evidence that higher baseline TSP is associated with greater improvements in resting pain following an exercise intervention. However, neither TSP nor EIH were associated with movement\u2010evoked pain changes. These findings highlight the potential clinical relevance of evaluating central pain mechanisms when designing rehabilitation strategies for pain relief in LBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70164","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T11:33:46Z","timestamp":1762428826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Baseline Pain Summation Predicts Resting but Not Movement Pain Relief After Exercise in Low Back Pain"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8234-8622","authenticated-orcid":false,"given":"Giovanna Laura Neves Antonio","family":"Gaban","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Federal University of S\u00e3o Carlos (UFSCar) S\u00e3o Carlos  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas Bloch","family":"Thorlund","sequence":"additional","affiliation":[{"name":"Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"},{"name":"Research Unit for General Practice, Department of Public Health University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian Kj\u00e6r\u2010Staal","family":"Petersen","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain, Department of Health Science and Technology Faculty of Medicine, Aalborg University  Aalborg Denmark"},{"name":"Center for Mathematical Modelling of Knee Osteoarthritis, Department of Materials and Production Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Graven\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain, Department of Health Science and Technology Faculty of Medicine, Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Schou","sequence":"additional","affiliation":[{"name":"Rehabilitation Center Hollufgaard, Odense Municipality  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-9947","authenticated-orcid":false,"given":"Henrik Bjarke","family":"V\u00e6gter","sequence":"additional","affiliation":[{"name":"Pain Research Group, Pain Center Odense University Hospital Odense  Odense Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30925\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/PM\/PNZ366"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2021.07.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13191"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001431"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000001158"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.01.027"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665\u20109913(23)00098\u2010X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)30489\u20106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000891"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000294"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000771"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009790.pub2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","unstructured":"Kahan R. 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