{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:11:42Z","timestamp":1783545102252,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Although calcitonin gene\u2010related peptide (CGRP) has emerged as a promising therapeutic target in migraine management, current clinical evidence regarding its dynamic variations in paediatric migraine populations remains inconclusive. We conducted a meta\u2010analysis to explore the relationship between blood CGRP levels and paediatric migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Databases and Data Treatment<\/jats:title>\n                    <jats:p>We systematically searched for observational studies that reported CGRP levels in paediatric migraine published in English from the PubMed, Web of Science, and Embase electronic databases, or in Chinese from the Chinese National Knowledge Infrastructure and the WanFang Med database. The Newcastle\u2013Ottawa Quality Assessment Scale was used to assess the quality of the included studies. The quality of evidence for each outcome was assessed according to the Grading of Recommendations, Assessment, Development, and Evaluation guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1134 identified studies, eight were eligible for inclusion. There was a \u2018Moderate\u2019 level of evidence demonstrating significantly elevated CGRP levels in children with migraine compared to controls (standardised mean difference [SMD]\u2009=\u20091.44, 95% CI 0.61\u20132.31). Stratification analysis showed the \u2018Low\u2019 level of evidence revealed higher levels during both ictal (SMD\u2009=\u20092.39, 95% CI 0.59\u20134.19) and interictal phases (SMD\u2009=\u20091.27, 95% CI 0.54\u20131.99). \u2018Very low\u2019 quality of evidence supported paediatric migraine patients with (SMD\u2009=\u20091.47, 95% CI 0.67\u20132.27) and without (SMD\u2009=\u20091.11, 95% CI 0.50\u20131.72) aura had higher CGRP levels than non\u2010migraine controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that CGRP levels may be a potential diagnostic biomarker and prophylactic therapeutic target for paediatric migraine, but need high\u2010quality longitudinal studies to validate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis provides significant evidence that CGRP levels serve as a potential diagnostic biomarker for migraine in children and adolescents. Future research should further explore the diagnostic value of CGRP levels in this population. However, the current evidence does not confirm CGRP as an acute\u2010phase therapeutic target for pediatric and adolescent migraine, necessitating validation through higher\u2010quality studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO number: CRD42025635332<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70177","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:00:58Z","timestamp":1764331258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Calcitonin Gene\u2010Related Peptide (\n                    <scp>CGRP<\/scp>\n                    ) Levels of Children and Adolescents With Migraine: A Systematic Review and Meta\u2010Analysis of Observational Studies"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-9493","authenticated-orcid":false,"given":"Guoliang","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Medicine University of Electronic Science and Technology of China  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3922-9893","authenticated-orcid":false,"given":"Juan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The First Affiliated Hospital of Chengdu Medical College  Chengdu 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