{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:52:15Z","timestamp":1768974735161,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006196","name":"Oulun Yliopisto","doi-asserted-by":"publisher","award":["24000692"],"award-info":[{"award-number":["24000692"]}],"id":[{"id":"10.13039\/501100006196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnssonin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["20227530"],"award-info":[{"award-number":["20227530"]}],"id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Musculoskeletal (\n MSK<\/jats:styled-content>\n ) pain and insomnia are interrelated and individually linked to reduced health\u2010related quality of life (\n HRQoL<\/jats:styled-content>\n ). This study aimed to enlighten the association of concurrent disabling\n MSK<\/jats:styled-content>\n pain and insomnia with\n HRQoL<\/jats:styled-content>\n among middle\u2010aged individuals.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Members of the Northern Finland Birth Cohort 1966 were surveyed at age 46\u2009years (analytic sample\n N<\/jats:italic>\n \u2009=\u20094\u2009130, 56.7% women). Validated Athens insomnia scale was used to determine insomnia status and\n HRQoL<\/jats:styled-content>\n was assessed with the\n 15D<\/jats:styled-content>\n (15\u2010dimensional) questionnaire. Associations between different combinations of disabling\n MSK<\/jats:styled-content>\n pain and insomnia (concurrent, isolated, absent) with\n HRQoL<\/jats:styled-content>\n were analysed using general linear regression, adjusting for sex, smoking, educational level, physical activity and coexisting diseases. Fifteen\n HRQoL<\/jats:styled-content>\n dimensions were also analysed separately.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The prevalence of concurrent disabling\n MSK<\/jats:styled-content>\n pain and insomnia was 14.3%, while 50.8% reported neither condition. Adjusted\n 15D<\/jats:styled-content>\n mean score of participants with concurrent disabling\n MSK<\/jats:styled-content>\n pain and insomnia was significantly lower (beta [\n \u03b2<\/jats:italic>\n ] coefficient: \u22120.068 [95%\n CI<\/jats:styled-content>\n \u22120.073 to \u22120.062]) compared to those without. Concurrent conditions were associated with lower\n HRQoL<\/jats:styled-content>\n than isolated insomnia and isolated disabling\n MSK<\/jats:styled-content>\n pain (\n \u03b2<\/jats:italic>\n coefficients: \u22120.032 [95%\n CI<\/jats:styled-content>\n \u22120.039 to \u22120.024] and \u22120.042 [95%\n CI<\/jats:styled-content>\n \u22120.050 to \u22120.034], respectively). Fourteen of 15\n HRQoL<\/jats:styled-content>\n dimensions were the lowest among participants with concurrent conditions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study shows that every seventh of the study population has disabling\n MSK<\/jats:styled-content>\n pain and insomnia concurrently and they are more strongly associated with lower\n HRQoL<\/jats:styled-content>\n compared to isolated or absent conditions. The negative effects of comorbid conditions on\n HRQoL<\/jats:styled-content>\n are reflected across multiple dimensions.\n <\/jats:p>\n <\/jats:sec>\n \n Significance Statement<\/jats:title>\n Musculoskeletal pain and insomnia together exert a compounded negative effect on health\u2010related quality of life, highlighting the need for integrated management strategies. Treating pain alone may not be enough and routine sleep assessment could be a critical point.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ejp.70197","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T13:12:27Z","timestamp":1767618747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Musculoskeletal Pain, Insomnia and Health\u2010Related Quality of Life: Associations in the Middle\u2010Aged General Population"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-3942","authenticated-orcid":false,"given":"Tuukka","family":"Korpela","sequence":"first","affiliation":[{"name":"University of Oulu Oulu Finland"},{"name":"Research Unit of Health Sciences and Technology, Faculty of Medicine University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"},{"name":"Wellbeing Services County of North Ostrobothnia Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2158-6042","authenticated-orcid":false,"given":"Jaro","family":"Karppinen","sequence":"additional","affiliation":[{"name":"Research Unit of Health Sciences and Technology, Faculty of Medicine University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"},{"name":"Wellbeing Services County of South Karelia Lappeenranta Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-3971","authenticated-orcid":false,"given":"Petteri","family":"Oura","sequence":"additional","affiliation":[{"name":"Research Unit of Health Sciences and Technology, Faculty of Medicine University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Paananen","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health University of Oulu Oulu Finland"},{"name":"Western Uusimaa Wellbeing Services County Western Uusimaa Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-5756","authenticated-orcid":false,"given":"Arnold Y. L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences The Hong Kong Polytechnic University Hong Kong SAR China"},{"name":"Research Institute for Smart Ageing The Hong Kong Polytechnic University Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-6678","authenticated-orcid":false,"given":"Ilona","family":"Merikanto","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health University of Oulu Oulu Finland"},{"name":"SleepWell Research Program, Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Orton Orthopaedics Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-491X","authenticated-orcid":false,"given":"Eveliina","family":"Heikkala","sequence":"additional","affiliation":[{"name":"Research Unit of Health Sciences and Technology, Faculty of Medicine University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"},{"name":"Wellbeing Services County of Lapland Rovaniemi Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30752\u20102"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5350\/SLEEP.HYPN.2017.19.0151"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11136\u2010014\u20100787\u20104"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SJPAIN.2014.01.001"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/JHEP.2002.31311"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PAIN.2014.09.014"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15402002.2022.2124994"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101867"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BERH.2010.01.012"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SLEEP.2019.04.015"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/EJP.1130"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S154852"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JPAIN.2008.12.001"},{"issue":"11","key":"e_1_2_12_15_1","first-page":"832","article-title":"What Are the Most Common Conditions in Primary Care? 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