{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T05:51:40Z","timestamp":1768974700471,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aerobic exercise leads to transient hypoalgesia, but little is known about these effects over extended periods. This study aimed to investigate exercise\u2010induced hypoalgesia (EIH) responses in healthy individuals during long\u2010distance running on a treadmill.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty healthy participants (18\u201350\u2009years) completed a 15\u2009km treadmill run. Pain sensitivity was assessed using pain pressure threshold (PPT) before and during the run. Additionally, cuff\u2010PPT (cPPT), cuff\u2010pressure pain tolerance threshold (cPTT), temporal summation of pain (TSP) and conditioned pain modulation (CPM) were assessed with pressure cuff algometry before and during the run. Data were analysed using repeated measures ANOVA. Exploratory subgroups, based on changes in PPT, were identified using latent growth mixture models, and logistic regression was used to predict subgroup membership.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant changes were observed over time for PPT, PTT, cPPT or CPM at the group level. TSP decreased significantly after 10 and 15\u2009km (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.004) when compared to baseline. Exploratory analysis identified two distinct subgroups: \u2018increasing PPT\u2019 and \u2018decreasing PPT\u2019. Subgroup membership was predicted using baseline CPM and EIH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study found no significant changes in PPT, cPPT, or CPM following aerobic exercise. A significant change was observed in TSP. CPM and EIH predicted changes in PPT during the 15\u2009km run (increasing vs. decreasing) in an explorative analysis. Further research should test if baseline tests can predict pro\u2010 or anti\u2010nociceptive responses to long\u2010distance running.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>These findings highlight the importance of individual variability in endogenous pain modulation during endurance exercise. The lack of group\u2010level effects underscores the need to move beyond average responses and consider subgroups when studying exercise\u2010induced hypoalgesia. Identifying distinct modulatory profiles may offer insight into personalized exercise interventions and reveal stable traits related to pain regulation. This has potential clinical implications for tailoring exercise as a pain management strategy and for identifying individuals at risk of negative or absent hypoalgesic responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70199","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:41:04Z","timestamp":1768408864000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Development of the Pain Threshold During a Long\u2010Distance Run"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8786-9477","authenticated-orcid":false,"given":"Jens Fr\u00f8jk Axel","family":"Dixen","sequence":"first","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine, Aalborg University  Gistrup Denmark"},{"name":"Center for Neuroplasticity and Pain (CNAP) Aalborg University  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene","family":"Ravn","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine, Aalborg University  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorvaldur Skuli","family":"Palsson","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Occupational Therapy Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Kj\u00e6r\u2010Staal","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine, Aalborg University  Gistrup Denmark"},{"name":"Center for Neuroplasticity and Pain (CNAP) Aalborg University  Gistrup Denmark"},{"name":"Center for Mathematical Modeling of Knee Osteoarthritis (MathKOA) Aalborg University  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Hoegh","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Faculty of Medicine, Aalborg University  Gistrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2018-0079"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2020-0032"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny057"},{"key":"e_1_2_11_5_1","first-page":"1337","article-title":"Examining Changes in Pain Sensitivity Following 8 Minutes of Cycling at Varying Exercise Intensities","volume":"17","author":"Antonio B. B.","year":"2024","journal-title":"International Journal of Exercise Science"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12171734"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw275"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1580"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare12020242"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000001106"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2196\/18694"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2018-0024"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-8425.2006.00207.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.958"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000294"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa212"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2101"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2024.12112"},{"key":"e_1_2_11_20_1","first-page":"1","article-title":"Pain Science in Practice (Part 7): How Is Descending Modulation of Pain Measured?","volume":"54","author":"Hoegh M.","year":"2024","journal-title":"Journal of Orthopaedic and Sports Physical Therapy"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1279"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.05.004"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/08990220.2016.1229178"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90061-7"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.07.006"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11040475"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.06.019"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12514"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.33.5.336"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003494"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1758-x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12181"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2015.01.009"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.09.006"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000143"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2016.02.013"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S384306"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001661"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/14034948221100099"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000531"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.4741"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000833"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2002.27140"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90069-8"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188930"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.03.005"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-012-2421-x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1508"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001235"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225849"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/02640414.2024.2352682"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2010.05.008"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000543"},{"key":"e_1_2_11_54_1","first-page":"158","article-title":"Similarities Between Exercise\u2010Induced Hypoalgesia and Conditioned Pain Modulation in Humans","volume":"155","author":"Vaegter H. B.","year":"2014","journal-title":"Pain (Amsterdam)"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.901"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000823"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2018-0087"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002396"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2015.05.004"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2020.04.003"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90293-F"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejp.70199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:53:04Z","timestamp":1768927984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.70199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ejp.70199"],"URL":"https:\/\/doi.org\/10.1002\/ejp.70199","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70199"}}