{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:26:22Z","timestamp":1792106782881,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Fibromyalgia (FM) is a multifactorial syndrome involving chronic pain and psychological distress. Psychological traits such as anxiety, depression, and catastrophising are linked to symptom severity. Genetic variability may contribute to these dimensions through mechanisms related to pain modulation and stress response.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To examine associations between selected genetic polymorphisms and psychological variables in women with FM.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cross\u2010sectional study was conducted in 67 women diagnosed with FM. Pain intensity, FM impact and psychological variables\u2014anxiety, depression and catastrophising\u2014were assessed using validated questionnaires. Saliva samples were collected and 10 SNPs were genotyped (\n COMT<\/jats:italic>\n rs4680,\n DRD3<\/jats:italic>\n rs6280,\n OPRM1<\/jats:italic>\n rs1799971,\n BDNF<\/jats:italic>\n rs6265,\n MAOA<\/jats:italic>\n rs1137070,\n FKBP5<\/jats:italic>\n rs1360780,\n IL6<\/jats:italic>\n rs1800796,\n TNF<\/jats:italic>\n rs1800629,\n IL10<\/jats:italic>\n rs1800896,\n IFITM3<\/jats:italic>\n rs12252). Correlations were assessed using Pearson or Spearman coefficients, and associations were examined using ANOVA or Kruskal\u2013Wallis with Tukey or Mann\u2013Whitney post hoc tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Pain intensity correlated with depression (\n r<\/jats:italic>\n \u2009=\u20090.476,\n p<\/jats:italic>\n \u2009<\u20090.001), catastrophising (\n r<\/jats:italic>\n \u2009=\u20090.414,\n p<\/jats:italic>\n \u2009<\u20090.001), and anxiety (\n r<\/jats:italic>\n \u2009=\u20090.314,\n p<\/jats:italic>\n \u2009=\u20090.009). Catastrophising was related to depression (\n r<\/jats:italic>\n \u2009=\u20090.615,\n p<\/jats:italic>\n \u2009<\u20090.001), anxiety (\n r<\/jats:italic>\n \u2009=\u20090.453,\n p<\/jats:italic>\n \u2009<\u20090.001), and kinesiophobia (\n r<\/jats:italic>\n \u2009=\u20090.445,\n p<\/jats:italic>\n \u2009<\u20090.001).\n BDNF<\/jats:italic>\n rs6265 was associated with catastrophising (\n p<\/jats:italic>\n \u2009=\u20090.044),\n OPRM1<\/jats:italic>\n rs1799971 with anxiety (\n p<\/jats:italic>\n \u2009=\u20090.030), and\n MAOA<\/jats:italic>\n rs1137070 with depression (\n p<\/jats:italic>\n \u2009=\u20090.020).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Psychological variables in FM are interrelated and linked to pain perception.\n BDNF<\/jats:italic>\n ,\n OPRM1<\/jats:italic>\n and\n MAOA<\/jats:italic>\n polymorphisms are associated with indices of psychological vulnerability, underscoring the importance of integrating genetic and psychological perspectives to understand variability in FM.\n <\/jats:p>\n <\/jats:sec>\n \n Significance Statement<\/jats:title>\n Genetic variability influences psychological vulnerability in fibromyalgia. Specific variants were associated with key psychological traits: BDNF rs6265 with pain catastrophising, OPRM1 rs1799971 with anxiety, and MAOA rs1137070 with depressive symptoms. These findings reveal an interplay between genetic and psychological factors that may guide more personalised strategies for managing fibromyalgia.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ejp.70201","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T17:15:07Z","timestamp":1767028507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations Between Genetic Polymorphisms and Psychological Variables in Women With Fibromyalgia: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3914-7355","authenticated-orcid":false,"given":"V\u00edctor","family":"Riquelme\u2010Aguado","sequence":"first","affiliation":[{"name":"Department of Basic Health Sciences Rey Juan Carlos University Madrid Spain"},{"name":"Research Group on Bases Anat\u00f3micas, Moleculares y del Desarrollo Humano (GAMDES) Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-8673","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Gonz\u00e1lez\u2010\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Research Group on Cognitive Neuroscience, Pain, and Rehabilitation (NECODOR), Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"},{"name":"Health Science UNIE University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1870-2410","authenticated-orcid":false,"given":"Silvia","family":"Di\u2010Bonaventura","sequence":"additional","affiliation":[{"name":"Research Group on Cognitive Neuroscience, Pain, and Rehabilitation (NECODOR), Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"},{"name":"Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine Rey Juan Carlos University Alcorc\u00f3n Spain"},{"name":"Fundaci\u00f3n Internacional para el Estudio y Tratamiento del Dolor PainCorp Foundation Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-0039","authenticated-orcid":false,"given":"Leonardo","family":"Rodr\u00edguez\u2010Lagos","sequence":"additional","affiliation":[{"name":"Research Group on Cognitive Neuroscience, Pain, and Rehabilitation (NECODOR), Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alazne Zabarte","family":"del Campo","sequence":"additional","affiliation":[{"name":"Research Group on Bases Anat\u00f3micas, Moleculares y del Desarrollo Humano (GAMDES) Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-4349","authenticated-orcid":false,"given":"Francisco","family":"G\u00f3mez\u2010Esquer","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences Rey Juan Carlos University Madrid Spain"},{"name":"Research Group on Bases Anat\u00f3micas, Moleculares y del Desarrollo Humano (GAMDES) Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-1490","authenticated-orcid":false,"given":"Gema","family":"D\u00edaz\u2010Gil","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences Rey Juan Carlos University Madrid Spain"},{"name":"Research Group on Bases Anat\u00f3micas, Moleculares y del Desarrollo Humano (GAMDES) Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-5831","authenticated-orcid":false,"given":"Antonio","family":"Gil\u2010Crujera","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences Rey Juan Carlos University Madrid Spain"},{"name":"Research Group on Bases Anat\u00f3micas, Moleculares y del Desarrollo Humano (GAMDES) Faculty of Health Sciences Rey Juan Carlos University Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3410\/M1\u201083"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11916\u2010013\u20100358\u20103"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.653611"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijchp.2017.07.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3516"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032587\u20104"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358\u2010020\u201000141\u20109"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806918819944"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0303573"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny008"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010018\u20101416\u20108"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002692"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.08.001"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16020275"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11195645"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1157\/13127277"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14040271"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155354"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.08.004"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13201719"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.05.060"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010007\u20100454\u2010y"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyu087"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002130"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20561"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010025\u201005905\u20104"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10880\u2010018\u20109543\u20101"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1003"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532\u20102149.2012.00153.x"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24097831"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.37349\/ei.2025.1003206"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104\u2010020\u201005226\u20108"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010025\u201004138\u20103"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010018\u20101726\u20105"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41405"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.03.013"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.2223"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12030671"},{"issue":"5","key":"e_1_2_13_41_1","first-page":"554","article-title":"The Fibromyalgia Impact Questionnaire: A Validated Spanish Version to Assess the Health Status in Women With Fibromyalgia","volume":"22","author":"Rivera J.","year":"2004","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"2","key":"e_1_2_13_42_1","first-page":"121","article-title":"Adaptaci\u00f3n Espa\u00f1ola del Inventario Para la Depresi\u00f3n de Beck\u2010II (BDI\u2010II): 3. Propiedades Psicom\u00e9tricas en Pacientes con Trastornos Psicol\u00f3gicos Spanish Adaptation of the Beck Depression Inventory\u2010II (BDI\u2010II): 3","volume":"16","author":"Sanz J.","year":"2005","journal-title":"Psychometric Features in Patiens With Psychological Disorders"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.22.1.197"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1054\/math.2002.0484"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277427"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2316"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105112"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.05.008"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21931"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010011\u20101990\u2010z"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010016\u20100607\u20106"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11055\u2010024\u201001603\u2010z"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168730"}],"container-title":["European Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ejp.70201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ejp.70201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:54:04Z","timestamp":1768928044000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejp.70201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ejp.70201"],"URL":"https:\/\/doi.org\/10.1002\/ejp.70201","archive":["Portico"],"relation":{},"ISSN":["1090-3801","1532-2149"],"issn-type":[{"value":"1090-3801","type":"print"},{"value":"1532-2149","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70201"}}