{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:06:17Z","timestamp":1776863177469,"version":"3.51.2"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_200482"],"award-info":[{"award-number":["32003B_200482"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P 198F"],"award-info":[{"award-number":["P 198F"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Health Research BC","doi-asserted-by":"publisher","award":["RT\u20102023\u20103173"],"award-info":[{"award-number":["RT\u20102023\u20103173"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R359\u20102020\u20102620"],"award-info":[{"award-number":["R359\u20102020\u20102620"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001708","name":"International Foundation for Research in Paraplegia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain\u2010related autonomic responses are increased after experimentally\u2010induced secondary mechanical hyperalgesia (SMH), as well as in a variety of chronic pain cohorts. In this state of sensitization, negative expectations further amplify these enhanced responses. Whether these pain\u2010related autonomic responses can also be modulated by positive expectations, i.e., placebo, was investigated in this experimental study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty healthy participants (20 females) were recruited and assigned to either a PLACEBO or a CONTROL group. Pain ratings and skin conductance responses (SCR) were recorded in response to five pinprick stimuli applied to the volar forearm at three timepoints: before and after experimental heat pain, and after an inert cream was applied to the volar forearm with instructions to enhance expectation for pain relief and conditioning (i.e., PLACEBO) or neutral instructions and no conditioning (i.e., CONTROL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pain ratings and SCR increased in both the PLACEBO and CONTROL groups after the application of the heat pain model, signalling the induction of secondary mechanical hyperalgesia (all\n                      <jats:italic>p<\/jats:italic>\n                      's\u2009&lt;\u20090.05). Both outcomes decreased after PLACEBO, returning to near baseline levels (both\n                      <jats:italic>p<\/jats:italic>\n                      's\u2009&lt;\u20090.05). In contrast, SCR and pain ratings remained elevated in the CONTROL group. The decrease in pain ratings and SCR observed in the PLACBO group were, however, not correlated (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results show that positive expectations shape both psychophysical and physiological pain\u2010related responses in a state of central sensitization. The lack of correlation between the placebo effect on pain ratings and on SCR implies different expectation\u2010related modulatory processes on the two pain responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Our findings provide evidence that pain\u2010related autonomic responses are modulated by expectations, even in a state of heightened sympathetic arousal, such as after experimentally\u2010induced sensitization in healthy participants. In the context of clinical assessments, this implies that caution is warranted when interpreting unprocessed pain\u2010related autonomic signals, such as SCR amplitudes, as surrogate markers of central sensitization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70259","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:45:44Z","timestamp":1774845944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placebo Effect on Pain\u2010Related Autonomic Responses in a State of Experimentally\u2010Induced Sensitization"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7241-565X","authenticated-orcid":false,"given":"Florin","family":"Allmendinger","sequence":"first","affiliation":[{"name":"Spinal Cord Injury Center Balgrist University Hospital, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Utz","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center Balgrist University Hospital, University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina Simonne","family":"Scheuren","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center Balgrist University Hospital, University of Zurich  Zurich Switzerland"},{"name":"International Collaboration on Repair Discoveries University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Anesthesiology, Pharmacology &amp; Therapeutics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Rosner","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center Balgrist University Hospital, University of Zurich  Zurich Switzerland"},{"name":"Danish Pain Research Center, Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Spinal Cord Injury Center of Western Denmark, University Clinic for Neurorehabilitation, Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Lawrence Kippling","family":"Kramer","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries University of British Columbia  Vancouver British Columbia Canada"},{"name":"Department of Anesthesiology, Pharmacology &amp; Therapeutics, Faculty of Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Hubli","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center Balgrist University Hospital, University of Zurich  Zurich Switzerland"},{"name":"Neuroscience Center Zurich (ZNZ), University of Zurich and ETH Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.70029"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.14744\/agri.2021.43078"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010clinpsy\u2010021815\u2010093015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010neuro\u2010101822\u2010122427"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002222"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010006\u20100587\u2010x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.04.028"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2012"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.17"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1907805"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.08.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.07.014"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1180142"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2191\u201013.2013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.11.029"},{"key":"e_1_2_11_17_1","unstructured":"Grimm J.2009.\u201cState\u2010Trait\u2010Anxiety Inventory Nach Spielberger.\u201dDeutsche Lang\u2010Und Kurzversion. 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