{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:19:42Z","timestamp":1779365982862,"version":"3.53.0"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Understanding the molecular architecture of peripheral sensory neurons is critical as we pursue novel drug targets against pain and neuropathy. Sensory neurons in the dorsal root ganglion (DRG) show extensive compartmentalization; thus, understanding each compartment\u2014from the peripheral to central terminals\u2014is key to this effort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To systematically profile this spatial complexity, we generated a TurboID\n                      <jats:sup>fl\/fl<\/jats:sup>\n                      transgenic mouse line (ROSA26\n                      <jats:sup>em1(TurboID)Bros<\/jats:sup>\n                      ), enabling targeted proximity labelling and deep proteomic profiling of DRG neuron compartments via Tg(Advillin\u2010Cre)\n                      <jats:sup>+<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our data reveal distinct proteomic signatures across neuronal compartments that reflect specialized neuronal functions. We provide proteomic insights into previously inaccessible nerve terminals both in the periphery (innervating the skin) and in the spinal cord. Further, using a DRG explant model of chemotherapy\u2010induced peripheral neuropathy, we uncover novel and discrete proteome changes, highlighting neuronal vulnerability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Together, our findings provide a unique proteome atlas of the sensory neuron proteome across anatomical domains and demonstrate the utility of proximity labelling proteomics for detecting compartment\u2010specific molecular alterations in a disease model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This study highlights the potential of TurboID\u2010based proteomics to uncover cell type\u2010specific differences in the peripheral nervous system, serving as a valuable resource for mechanistic studies of sensory neuron function and pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70277","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:23:48Z","timestamp":1777267428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-2159","authenticated-orcid":false,"given":"Julia R.","family":"Sondermann","sequence":"first","affiliation":[{"name":"Systems Biology of Pain, Division of Pharmacology &amp; 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