{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T12:18:31Z","timestamp":1779365911212,"version":"3.53.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Wound\u2010related pain represents a significant unmet clinical need. To advance its understanding and treatment, there is a need for a validated preclinical model for the study of wound\u2010related pain in both sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 1.2\u2009cm incision was created on the hairy skin of the dorsum of male and female Sprague\u2013Dawley rats posterior to L4. In the first study, mechanical withdrawal thresholds at the dorsum and hind paws were assessed for 34\u2009days post\u2010incision in both male and female rats to investigate the temporal profile of mechanical hypersensitivity following a dorsum incision. The second study investigated the effects of morphine (3\u2009mg\/kg\u2009s.c.) on mechanical hypersensitivity in the dorsum and hind paws on post\u2010incision Day 8 in male Sprague\u2013Dawley rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Robust mechanical hypersensitivity was evident in the dorsum up to 14\u2009days post\u2010incision in males and 7\u2009days post\u2010incision in females, indicating sex differences in the temporal profile of mechanical hypersensitivity following incision. Secondary mechanical hypersensitivity was present in the hind paws of both sexes following a dorsum incision. Morphine (3\u2009mg\/kg\u2009s.c.) significantly attenuated dorsum and hind paw mechanical hypersensitivity on post\u2010incision Day 8.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that the dorsum incision model is suitable for modelling incisional wound\u2010related pain and exhibits sex differences in pain\u2010related behaviour post\u2010incision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>This paper extends the characterisation of an animal model of incisional wound\u2010related pain, in both sexes. It represents an advancement in the ability to model this condition pre\u2010clinically and will facilitate investigation of underlying mechanisms and novel therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70284","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:11:26Z","timestamp":1778242286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Behavioural Characterisation and Pharmacological Validation of an Incisional Wound\u2010Related Pain Model"],"prefix":"10.1002","volume":"30","author":[{"given":"Catherine R.","family":"Healy","sequence":"first","affiliation":[{"name":"Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, Institute for Health Discovery and Innovation University of Galway  Galway City Ireland"},{"name":"Galway Neuroscience Centre University of Galway  Galway City Ireland"},{"name":"Centre for Pain Research University of Galway  Galway City Ireland"},{"name":"C\u00daRAM, Research Ireland Centre for Medical Devices University of Galway  Galway City Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, Institute for Health Discovery and Innovation University of Galway  Galway City Ireland"},{"name":"Galway Neuroscience Centre University of Galway  Galway City Ireland"},{"name":"Centre for Pain Research University of Galway  Galway City Ireland"},{"name":"C\u00daRAM, Research Ireland Centre for Medical Devices University of Galway  Galway City Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, Institute for Health Discovery and Innovation University of Galway  Galway City Ireland"},{"name":"Galway Neuroscience Centre University of Galway  Galway City Ireland"},{"name":"Centre for Pain Research University of Galway  Galway City Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Gethin","sequence":"additional","affiliation":[{"name":"C\u00daRAM, Research Ireland Centre for Medical Devices University of Galway  Galway City Ireland"},{"name":"School of Nursing and Midwifery University of Galway  Galway City Ireland"},{"name":"Alliance for Research and Innovation in Wounds University of Galway  Galway City Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay","family":"Pandit","sequence":"additional","affiliation":[{"name":"C\u00daRAM, Research Ireland Centre for Medical Devices University of Galway  Galway City Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-621X","authenticated-orcid":false,"given":"David P.","family":"Finn","sequence":"additional","affiliation":[{"name":"Pharmacology and Therapeutics, School of Pharmacy and Medical Sciences, Institute for Health Discovery and Innovation University of Galway  Galway City Ireland"},{"name":"Galway Neuroscience Centre University of Galway  Galway City Ireland"},{"name":"Centre for Pain Research University of Galway  Galway City Ireland"},{"name":"C\u00daRAM, Research Ireland Centre for Medical Devices University of Galway  Galway City Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1209"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215704"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108131"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcws.2008.12.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2024.104752"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atc.2004.11.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1505980"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90133-5"},{"key":"e_1_2_9_10_1","first-page":"113","article-title":"Reduction of Postincisional Allodynia by Subcutaneous Bupivacaine: Findings With a New Model in the Hairy Skin of the Rat","volume":"103","author":"Duarte A. 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