{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:04:56Z","timestamp":1779368696284,"version":"3.53.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pain is a widespread condition with significant individual and societal impact. Overweight has been associated with a higher risk of chronic pain, whereas physical activity may act as a protective factor. The aim of this study was to investigate whether physical activity and BMI interact in their association with chronic pain, and whether this interaction differs across age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study used data from the 2021 Danish Capital Region Health Survey, comprising 56,245 participants aged 16\u2009years or older. After excluding participants with missing data, 49,879 participants were included in the analyses. Information on chronic pain, BMI, and physical activity was self\u2010reported. Descriptive statistics and multiple logistic regression analyses, weighted for sampling procedures and non\u2010response, were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the total study population, 33.8% reported chronic pain. The combination of obesity and sedentary behaviour was associated with the highest odds of chronic pain compared with participants of normal weight and low physical activity. Overall, both obesity and sedentary behaviour were associated with increased odds of chronic pain across all physical activity and BMI groups, particularly among adults aged 35+ years. However, little to no evidence of a multiplicative interaction between physical activity and BMI was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both obesity and sedentary behaviour were associated with higher odds of having chronic pain. The associations were stronger among older adults. The results highlight the importance of addressing both obesity and sedentary behaviour in future prevention and management strategies of chronic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This large cross\u2010sectional study highlights that both sedentary behaviour and obesity are independently associated with higher odds of chronic pain. Although little to no evidence of an interaction between physical activity and BMI was found, the findings underscore the importance of addressing both factors, particularly among adults aged 35+ years, to inform chronic pain prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70292","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:28:47Z","timestamp":1778596127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["No Interaction Between Physical Activity and Body Mass Index on Chronic Pain: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Julie","family":"Mundt","sequence":"first","affiliation":[{"name":"Center for Clinical Research and Prevention, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg  Frederiksberg Denmark"},{"name":"Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette Reffstrup","family":"Christensen","sequence":"additional","affiliation":[{"name":"Research Unit of General Practice  Aarhus Denmark"},{"name":"Research Unit of General Practice, Department of Public Health, Faculty of Health Sciences University of Southern Denmark  Odense Denmark"},{"name":"DRIVEN, Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstine Skov","family":"Benthien","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Endocrine, and Hormone Diseases Copenhagen University Hospital\u2014Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1464-8719","authenticated-orcid":false,"given":"Marie Holm","family":"Eliasen","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Prevention, Copenhagen University Hospital\u2014Bispebjerg and Frederiksberg  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889\u2010016\u20103696\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2019.01.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110025"},{"issue":"4","key":"e_1_2_11_5_1","first-page":"46","article-title":"Differences in Self\u2010Reported Physical Activity, Exercise Self\u2010Efficacy and Outcome Expectancies, and Health Status by Body Mass Index Groups in People With Chronic Pain","volume":"84","author":"Brooks J. 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