{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:32:10Z","timestamp":1788330730105,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007\u20102013"],"award-info":[{"award-number":["FP7\/2007\u20102013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Topical high\u2010dose capsaicin acting on\n                      <jats:styled-content style=\"fixed-case\">TRPV<\/jats:styled-content>\n                      1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (\n                      <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>\n                      ). Sensory changes after capsaicin application, their correlation with pain relief and their role as possible predictors of response have been insufficiently analysed. We hypothesized a positive correlation between pain relief and increase in the warmth detection threshold (\n                      <jats:styled-content style=\"fixed-case\">WDT<\/jats:styled-content>\n                      ), indicating loss of C\u2010fibre function, and higher response rates in patients with preserved C\u2010fibre function or heat hyperalgesia before application.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Quantitative Sensory Testing (\n                      <jats:styled-content style=\"fixed-case\">DFNS<\/jats:styled-content>\n                      protocol) was conducted in 20 unilaterally treated patients with peripheral\n                      <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>\n                      (peripheral nerve injury:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a014, polyneuropathy:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04, postherpetic neuralgia:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02) before and 2, 4, 6 and 8\u00a0weeks after application of capsaicin (8%) in this open\u2010label study. Response was defined as \u226530% or \u22652 (Numeric Rating Scale: 0\u201310) decrease of current pain at any follow\u2010up compared to baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In all patients,\n                      <jats:styled-content style=\"fixed-case\">WDT<\/jats:styled-content>\n                      significantly increased 8\u00a0weeks after capsaicin application, but did not correlate with pain relief in responders (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010,\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.179,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.141). Before treatment, responders showed significantly higher\n                      <jats:italic>z<\/jats:italic>\n                      \u2010values for the cold (\n                      <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>\n                      , +0.7\u00a0\u00b1\u00a01.1 vs. \u22120.4\u00a0\u00b1\u00a00.9) and mechanical pain threshold (\n                      <jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content>\n                      ; 0.7\u00a0\u00b1\u00a02.5 vs. \u22121.2\u00a0\u00b1\u00a01.3), but did not differ from non\u2010responders regarding\n                      <jats:styled-content style=\"fixed-case\">WDT<\/jats:styled-content>\n                      or heat pain threshold. A sum of the z\u2010values for\n                      <jats:styled-content style=\"fixed-case\">CPT<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content>\n                      &gt;0.8 before treatment identified responders with 100% specificity and 70% sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Efficacy of capsaicin does not correlate with the induced loss of function of small fibres, measured by\n                      <jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>\n                      . Presence of cold and pinprick hyperalgesia seems to be predictive of response to capsaicin (8%).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.703","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T20:03:02Z","timestamp":1428523382000},"page":"116-129","source":"Crossref","is-referenced-by-count":77,"title":["Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain"],"prefix":"10.1002","volume":"20","author":[{"given":"T.","family":"Mainka","sequence":"first","affiliation":[{"name":"Department of Pain Medicine Berufsgenossenschaftliches Universit\u00e4tsklinikum Bergmannsheil GmbH Ruhr\u2010University Bochum Germany"},{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf 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