{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:25:12Z","timestamp":1788449112173,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic pain frequently co\u2010occurs with emotional problems, highlighting the need for integrated treatment approaches. Previously, we evaluated a hybrid emotion\u2010focused treatment with positive results. However, there is a dire need for studies evaluating treatments in \u2018real world\u2019 clinical contexts. Therefore, this study evaluated the effectiveness of this treatment in regular clinical care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using a sequential single\u2010case experimental AB design with randomized baseline lengths (4, 5 or 6\u2009weeks), pain, emotional problems and cognitive behavioural factors were assessed weekly across a 20\u2010week study period. Additional outcome measurements were collected at pre\u2010, post\u2010 and 12\u2010month follow\u2010up. Patients from primary and secondary care (final\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931) with chronic pain and anxiety\/depression were recruited, and their psychologists delivered the treatment. Individual effects were evaluated using non\u2010overlap of all pairs and aggregated effects via multilevel shift models. Acceptability, adherence and fidelity were summarized, and responders and non\u2010responders compared using group\u2010level analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most (87%) demonstrated a treatment response on \u2265\u20091 outcome, and over half (55%) on \u2265\u20093 outcomes. One\u2010third were classified as broad responders. Aggregated analysis showed a significant effect on pain interference. The treatment was viewed as credible and acceptable, with greater satisfaction among responders. Non\u2010responders showed more variability in attendance and lower progression through later treatment phases involving exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings support the feasibility and potential effectiveness of the hybrid emotion\u2010focused treatment for patients in routine clinical care. The treatment benefits most patients to some extent and a smaller subset of patients to a clinically significant extent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>This pragmatic trial evaluates effectiveness in a clinically representative patient sample reflecting the complexity of routine care, including pain and psychiatric comorbidity, sociodemographic diversity and health care utilization. The hybrid emotion\u2010focused treatment represents one of several emerging approaches targeting pain\u2013emotion connections. These findings extend results from a prior RCT and highlight the importance of evaluating interventions under real\u2010world clinical conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70310","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:46:58Z","timestamp":1781358418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of a Transdiagnostic Emotion\u2010Focused Treatment in Clinical Care: A Sequential Single\u2010Case Experimental Design"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4219-5075","authenticated-orcid":false,"given":"Hedvig","family":"Zetterberg","sequence":"first","affiliation":[{"name":"Department of Education, Psychology and Social Work Mid Sweden University  \u00d6stersund Sweden"},{"name":"Center for Health and Medical Psychology, School of Behavioral, Social, and Legal 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