{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:24:36Z","timestamp":1787217876346,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pain"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic postsurgical pain (CPSP) after video\u2010assisted thoracoscopic surgery (VATS) is common, yet clinicians lack tools to identify high\u2010risk patients at routine follow\u2010up. We hypothesized that pain with neuropathic characteristics at 2\u2009weeks, signifying central sensitization, could stratify risk and guide precision analgesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled 500 adults undergoing VATS lung resection. Two logistic models were developed: one using variables on postoperative day 1 (POD1), and another adding neuropathic pain features on POD14. The primary outcome was CPSP at 3\u2009months, defined as a Numerical Rating Scale [NRS] score \u2265\u20091 for pain in the surgical region that was not present preoperatively and was not attributable to malignancy or infection; sensitivity analysis was conducted using NRS \u2265\u20093. Discrimination (area under the curve [AUC]), calibration and decision curve analysis quantified predictive performance and potential clinical applicability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 483 patients analysed, 247 (51.1%) developed CPSP and 184 (38.1%) had 3\u2010mon NRS \u2265\u20093. The POD14 model (sex, surgery type, chest tube duration, pain intensity, pain with neuropathic characteristics) was superior (AUC 0.904, 95% CI: 0.872\u20130.936) to the POD1 model (AUC 0.865, 95% CI: 0.827\u20130.903). Neuropathic pain at 2\u2009weeks was the strongest predictor (odds ratio 13.98, 95% CI: 2.90\u201367.38). Temporal validation confirmed discrimination with good calibration. Sensitivity analysis showed an AUC of 0.786 (95% CI: 0.737\u20130.835) for the POD14 model; pain with neuropathic characteristics retained strong predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This 5\u2010item tool with neuropathic pain features at 2\u2010week visit identifies patients at high risk for CPSP after VATS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance Statement<\/jats:title>\n                    <jats:p>Translating central sensitization from a theoretical mechanism to an actionable bedside tool, this study demonstrates that neuropathic pain features captured at routine two\u2010week follow\u2010up stratify risk for CPSP after VATS. This 5\u2010item model is a first step toward individualized CPSP risk stratification after VATS and requires external validation before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ejp.70360","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:09:51Z","timestamp":1786961391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 5\u2010Item Prediction Model Incorporating Pain With Neuropathic Characteristics at 2\u2009Weeks for Chronic Postsurgical Pain After Video\u2010Assisted Thoracoscopic Lung Surgery: A Prospective Cohort Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Wei","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"},{"name":"Institute of Anesthesiology Soochow University  Suzhou Jiangsu 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